Cotargeting a MYC/eIF4A-survival axis improves the efficacy of …
2023年8月8日 · Here, we show that an eIF4A inhibitor, which targets a component of eIF4F, dramatically enhances the effects of KRAS G12C inhibitors in NSCLCs and together these …
JCI - Cotargeting a MYC/eIF4A-survival axis improves the efficacy …
2023年6月29日 · Here, we show that an eIF4A inhibitor, which targets a component of eIF4F, dramatically enhances the effects of KRAS G12C inhibitors in NSCLCs and together these …
Targeting translation initiation by synthetic rocaglates for …
2019年6月6日 · Translation initiation inhibitor rocaglates have been identified as the most potent drugs in MYC-driven lymphomas as they efficiently inhibit MYC expression and tumor cell …
Effective Inhibition of MYC-Amplified Group 3 Medulloblastoma …
To explore the therapeutic mechanism of eIF4A inhibition against MYC-amplified G3-MB, we firstly measured the time-dependent changes of MYC protein levels of MYC-amplified G3-MB …
Critical and differential roles of eIF4A1 and eIF4A2 in B-cell ...
2024年11月8日 · Eukaryotic initiation factor 4 A (eIF4A) plays critical roles during translation initiation of cellular mRNAs by forming the cap-binding eIF4F complex, recruiting...
Inhibition of MYC translation through targeting of the newly …
2023年6月29日 · We demonstrated that inhibition of translation in CLL targets the MYC oncogene, leading to decreased proliferative capacities and reversion of metabolic rewiring. …
eIF4A dependency: the hidden key to unlock KRAS mutant non …
2023年12月12日 · The eIF4A is a relevant vulnerability in KRAS mutant NSCLC. In KRAS-driven tumors with high MYC levels, treatment with KRASi or MEKi induces a cytostatic response. …
Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC …
2021年5月17日 · We propose that targeting eIF4A, as well as mutant KRAS, provides novel methods to improve the efficacy of anti-PD-1 and associated ICB therapies against PDACs, in …
Targeted inhibition of eIF4A suppresses B-cell receptor-induced ...
We demonstrated that eIF4Ai (silvestrol and rocaglamide A) reduced anti-IgM-induced global mRNA translation in CLL cells and also inhibited accumulation of MYC and MCL1, key drivers …
Targeted intervention of eIF4A1 inhibits EMT and metastasis of ...
2021年12月14日 · Overexpression of eIF4A1 downregulated E-cadherin expression through the c-MYC/miR-9 axis, which promoted EMT and metastasis of pancreatic cancer cells. Despite …