An in-frame 3-bp deletion mutation in MYH6, in which one residue in MHC-α is removed, enhances the binding of MHC-α to myosin binding protein-C and disrupts normal sarcomere function and cardiac atrial conduction velocity.

2024年12月25日 · MYH6 (Myosin Heavy Chain 6) is a Protein Coding gene. Diseases associated with MYH6 include Atrial Septal Defect 3 and Cardiomyopathy, Dilated, 1Ee. Among its related pathways are Cytoskeleton remodeling Regulation of …

The MYH6 gene provides instructions for making a protein known as the cardiac alpha (α)-myosin heavy chain. This protein is found in heart (cardiac) muscle cells, where it forms part of a larger protein called type II myosin.

The mutations in MYH6 cause when a genetic cause can be identified, which has estimated to occur in 65% of hypertrophic cardiomyopathy. Our data provide evidence for a novel form of calcium-independent positive inotropy in failing cardiac myocytes by fast alpha-myosin motor protein gene transfer.

2024年3月11日 · myh6能够通过调节肌肉纤维中的atp水解反应来控制肌肉的收缩速度和力量，并且能够识别和结合肌钙蛋白以实现对钙离子的调控。 MYH6在心脏肌肉中的表达量与心脏功能密切相关，对心脏的正常收缩与舒张过程起着重要作用。

Cardiac muscle Myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac Myosin. The gene is located approximately 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac Myosin.

2025年2月8日 · Title: Myh6-driven Cre recombinase activates the DNA damage response and the cell cycle in the myocardium in the absence of loxP sites. A New Mouse Model of Chronic Myocarditis Induced by Recombinant Bacille Calmette-Guerin Expressing a T-Cell Epitope of Cardiac Myosin Heavy Chain-alpha.

位于线粒体和肌原纤维中。是肌肉肌球蛋白复合物的一部分。充血性心力衰竭、甲状腺功能减退和心肌梗死的生物标志物。该基因的人类同源物涉及心房间隔缺损（多种）；心脏传导疾病（多种）；和固有心肌病（多种）。与人类myh6（肌球蛋白重链6）正交。

MYH6，即肌球蛋白重链6，别名α-MHC、MyHC-alpha等。它是一种在心脏肌肉中表达的肌球蛋白，属于MYB/MYH基因家族的一员。MYH6在肌肉收缩过程中发挥重要作用，是肌肉纤维收缩的关键分子。其作用机制涉及到心脏肌肉细胞的收缩功能，与心脏的泵血能力密切相关。

用于研究扩张型心肌病；扩张型心肌病1EE；和肥厚型心肌病14。 这个基因的人类同源物涉及房间隔缺损（多种）；心脏传导疾病（多种）；和固有心肌病（多种）。 与人类MYH6（肌球蛋白重链6）正交。 [由基因组资源联盟，2022年4月提供] Genome sequence of the Brown Norway rat yields insights into mammalian evolution. 微丝马达活性。 参与心脏肌肉收缩。 在几个过程的上游或内部发挥作用，包括成年心脏发育；肌肉细胞发育；和心脏收缩的调节。 位于Z带和应力纤 …