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    Mannan-binding lectin - Wikipedia

    • Mannose-binding lectin (MBL), also called mannan-binding lectin or mannan-binding protein (MBP), is a lectin that is instrumental in innate immunity as an opsonin and via the lectin pathway. 展开

    Structure

    MBL has an oligomeric structure (400-700 kDa), built of subunits that contain three presumably identical peptide chains … 展开

    Function

    MBL belongs to the class of collectins in the C-type lectin superfamily, whose function appears to be pattern recognition in the first line of defense in the pre-immune host. MBL recognizes carbohydrate patterns found on the surf… 展开

    代号MBL2; COLEC1; HSMBPC; MBL; MBL2D; MBP; MBP-C; MBP1; MBPD
    Clinical significance

    It is produced in the liver as a response to infection, and is part of many other factors termed acute phase proteins. Expression and function in other organs were also suggested. The three structural polymorphisms o… 展开

    External links

    Mannan-Binding+Lectin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) 展开