MAP2 serves to stabilize MT growth by crosslinking MT with intermediate filaments and other MTs. MAP2 isoforms are neuron-specific cytoskeletal proteins enriched in dendrites and perikarya, implicating a role in determining and stabilizing …

2023年4月5日 · MAP2包括三种亚型：MAP2a、MAP2b和MAP2c。 其中MAP2b和MAP2c出现较早。 随着年龄的增长MAP2被组织蛋白酶D所降解，在不同类型的神经元中表达量存在差异。

Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic marker. It influences microtubule dynamics and microtubule/actin interactions to control neurite outgrowth and synaptic functions, similarly to the closely related MAP Tau.

2025年3月4日 · Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology. Specific phosphorylation of microtubule-associated protein 2c by extracellular signal-regulated kinase reduces interactions at its Pro-rich regions.

2024年12月25日 · MAP2 (Microtubule Associated Protein 2) is a Protein Coding gene. Diseases associated with MAP2 include Central Neurocytoma and Olivopontocerebellar Atrophy. Among its related pathways are TGF-Beta Pathway and CNTF Signaling. Gene Ontology (GO) annotations related to this gene include structural molecule activity and calmodulin binding.

特别是，微管相关蛋白2（map2）家族是大量的细胞骨架成分，主要在神经元中表达，并充当神经元中大多数蛋白激酶和磷酸酶的底物。 MAP2磷酸化似乎控制着它与细胞骨架的联系，并且受到发育的调节。

Microtubule-associated proteins (MAPs) are a family of proteins that influence this property. We showed previously that MAP2, a neuron-specific protein that stabilizes microtubules in the dendrites of postmitotic neurons, is induced in primary cutaneous melanoma but is absent in metastatic melanomas.

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2019年4月8日 · MICROTUBULE-ASSOCIATED PROTEIN 2, abbreviated MAP2, is a common immunostain used in neuropathology and pulmonary pathology. It's expression is associated with neuronal, glial or neuroendocrine differentiation

Microtubule-associated protein 2 (MAP2) is a neuronal phosphoprotein that regulates the structure and stability of microtubules, neuronal morphogenesis, cytoskeleton dynamics, and organelle trafficking in axons and dendrites (1).