2021年4月10日 · Purpose: We report the clinical outcomes of a randomized trial comparing prophylactic whole-pelvic nodal radiotherapy to prostate-only radiotherapy (PORT) in high-risk prostate cancer.

2021年1月26日 · The present randomized trial of prostate-only or whole-pelvic radiation therapy in high-risk prostate cancer (POP-RT) evaluated the benefit of treating the pelvic nodes for node-negative, high-risk prostate adenocarcinoma undergoing dose-escalated and moderately hypofractionated radiotherapy.

2020 年，POP-RT 试验确立了选择性全骨盆放疗在淋巴结浸润风险超过 35%（称为 Roach 公式）的患者中的作用。 POP-RT 强调了患者选择的重要性。 大型回顾性研究表明，在 cN1（临床淋巴结阳性）疾病或 pN1（病理淋巴结阳性）疾病患者中，与单独雄激素剥夺疗法相比 ...

2024年10月1日 · The POP-RT phase 3 randomized trial showed improved biochemical failure-free survival and metastasis-free survival with whole pelvic radiation therapy versus prostate-only radiation therapy for high and very high-risk prostate cancer, albeit with worse RTOG late …

In 2020, the POP-RT trial established the role of elective whole pelvis radiotherapy in patients who have more than a 35% risk of lymph node invasion (known as the Roach formula). POP-RT stressed the importance of patient selection.

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2023年10月1日 · Whole pelvic radiotherapy (WPRT) showed better biochemical failure-free survival and metastasis-free survival than prostate-only radiotherapy (PORT) in the phase III randomized POP-RT trial for high and very high-risk prostate cancer, albeit with higher RTOG grade 2 late urinary toxicity.

POP-RT provides invaluable information in this urological puzzle. Prophylactic pelvic irradiation for high-risk, locally advanced prostate cancer improved BFFS and DFS as compared with PORT, but OS did not appear to differ.

Prostate-Only Versus Whole-Pelvic Radiation Therapy in High-Risk and Very High-Risk Prostate Cancer (POP-RT): Outcomes From Phase III Randomized Controlled Trial. We report the clinical outcomes of a randomized trial comparing prophylactic whole-pelvic nodal radiotherapy to prostate-only radiotherapy (PORT) in high-risk prostate cancer.

Pelvic nodal recurrence is one of the most commonly observed sites of relapse of prostate cancer after curative treatment of the primary. Different radiation therapy (RT) strategies have been proposed for salvage treatment of nodal oligorecurrent patients, ranging from focal stereotactic body RT to superextended lymph node irradiation. 1