2024年12月25日 · MAP3K11 (Mitogen-Activated Protein Kinase Kinase Kinase 11) is a Protein Coding gene. Diseases associated with MAP3K11 include Dementia and Gastric Cancer. Among its related pathways are Signaling downstream of RAS mutants and G-protein signaling RAC1 in cellular process.

Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene. [5][6] The protein encoded by this gene is called MLK3 and it is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a …

MAP3K11 as a candidate gene for left ventricular hypertrophy High MLK3 phosphorylation promotes invasion of colorectal cancer. This study identified two distinct peptide-binding sites in the SH3 domain of MLK3, providing critical insights into mechanisms of ligand binding by the mixed-lineage kinase family of kinases.

2020年7月24日 · Mixed lineage kinase 3 (MLK3), a member of MAP3K family and also known as MAP3K11, is thought to be involved in several diseases, including cancer, pulmonary fibrosis, and...

Efficient regulation of type I interferon and NF-κB signaling by members of the mitogen-activated protein (MAP) kinase kinase kinase (MAP3K) family plays an important role in antiviral immunity. Elucidating the specific roles of MAP3K activation during viral infection is essential to develop effective antiviral therapies.

该激酶包含一个 SH3 结构域和一个亮氨酸拉链基序。 该激酶优先激活 MAPK8/ JNK 激酶，并作为 JNK 信号通路的正调节剂发挥作用。 该激酶可直接磷酸化并激活 IkappaB 激酶 alpha 和 beta，被发现参与由 Rho 家族 GTP 酶和 CDC42 介导的 NF-kappaB 的转录活性。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif.

Results: Utilizing engineered tumour models we identified MAP3K11/GDF15 pathway activation as a potent inducer of cancer cachexia. Increased expression and high circulating levels of GDF15 acted as a key mediator of this process.

2024年8月27日 · MAP3K11 facilitates autophagy activity and is correlated with malignancy of oral squamous cell carcinoma. The role of mixed lineage kinase 3 (MLK3) in cancers. Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division.

Title: MAP3K11 facilitates autophagy activity and is correlated with malignancy of oral squamous cell carcinoma.

这个激酶优先激活MAPK8/JNK激酶，并作为JNK信号通路的正调节剂发挥作用。 这个激酶可以直接磷酸化和激活IkappaB激酶α和β，并发现涉及由Rho家族GTPases和CDC42介导的NF-kappaB转录活性。 [由RefSeq，2008年7月提供] Dir./Indir. Human chromosome 11 DNA sequence and analysis including novel gene identification. Patterns …