Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, [5] which is located on the long arm of chromosome 17 (17q23.3). [6] This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse MEKK3.

2024年12月25日 · MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3) is a Protein Coding gene. Diseases associated with MAP3K3 include Verrucous Hemangioma and Capillary Malformation-Arteriovenous Malformation 1. Among its related pathways are NGF Pathway and Interleukin-1 family signaling.

MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. [ 11 ] MAP3K7 (TAK1) participates in regulation of transcription by transforming growth factor-beta ( TGF-beta ).

2023年6月7日 · In vivo, MAP3K3 knockdown reduces IFN-I induction and increases the susceptibility to herpes simplex virus type 1 (HSV-1) infection. Endogenous MAP3K3 binds to and phosphorylates IRF7 upon the binding of TLR9 to its specific ligand CpG DNA.

Phosphorylation at Ser-166 and Ser-337 by SGK1 inhibits its activity. Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a complex with MAP2K3, RAC1 and CCM2. Interacts with MAP2K5 and SPAG9. Search… Showing features for domain, compositional bias, region. Belongs to the protein kinase superfamily.

MAP3Ks play several roles during viral infection and have reciprocal efects on virus survival. After viral infec-tion, MAP3Ks regulate the production of interferons, inflam-matory mediators, and other antiviral substances through antiviral pathways, which are …

2024年12月6日 · Human MEKK3 (MAP3K3) is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2 (MAP3K2; 609487), tobacco NPK, and yeast Ste11.

2024年12月25日 · MAPK3 (Mitogen-Activated Protein Kinase 3) is a Protein Coding gene. Diseases associated with MAPK3 include Autism Spectrum Disorder and Epilepsy. Among its related pathways are Prolactin Signaling and Toll Like Receptor 7/8 (TLR7/8) Cascade.

Gene/transcipt that contains an open reading frame (ORF). Protein coding. A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.

In this review, we discuss members of the MAP3K family and correlate their mRNA expression levels to patient survival outcomes in different cancers.