2019年11月5日 · Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1-mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22-induced BIK1 activation.

2019年9月2日 · Our results uncover that a Hippo/ STE 20 homolog, MAP 4K4, maintains the homeostasis of the central immune component BIK 1. The receptor‐like cytoplasmic kinase BIK 1 serves as a central signaling hub during PAMP ‐triggered immunity in plants.

MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22-induced BIK1 activation. Our results uncover that a Hippo/STE20 homolog, MAP4K4, maintains the homeostasis of the central immune component BIK1. Keywords BIK1; Flg22 ...

MAP4K4, which is localized in the cytosol and at the plasma membrane, phosphorylates PP2C38 in the presence of flg22, and phosphorylated PP2C38 disassociates from BIK1, indicating that MAP4K4 also regulates BIK1 activity through controlling PP2C38 (Jiang et al., 2019).

Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1-mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22-induced BIK1 activation.

Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1-mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22-induced BIK1 activation.

SIK1 and MAP4K4 stabilize BIK1 by phosphorylation. PP2C38 maintains BIK1 activity at minimum levels. Upon flg22 treatment, BIK1 is released from FLS2 and BAK1. MAP4K4 phosphorylates PP2C38 at Ser77, thereby enabling BIK1 activation. In parallel or alternatively, SIK1 and MAP4K4 phosphorylate and stabilize BIK1.

2019年9月2日 · Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1-mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1...

2019年9月2日 · MAP 4K4 associates and phosphorylates BIK 1 at Ser233, Ser236, and Thr242 to ensure BIK 1 stability and activity. Furthermore, MAP 4K4 phosphorylates PP 2C38 at Ser77 to enable flg22‐induced BIK 1 activation. Our results uncover that a Hippo/ STE 20 homolog, MAP 4K4, maintains the homeostasis of the central immune component BIK 1.

The authors provide evidence for a compromised immune signaling in map4k4 plants, demonstrate in vivo interaction between MAP4K4 and BIK1, and show that MAP4K4 phosphorylates BIK1 and suggest that this regulates its proteasome-dependent protein turnover.