2018年8月31日 · Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic diseases (i.e SLE, Juvenile idiopathic arthritis, Adult onset Still’s disease). It manifests as uncontrolled activation and proliferation of T lymphocytes and macrophages

2022年5月24日 · 巨噬细胞活化综合征（macrophage activation syndrome，MAS）是HLH的一种类型，特指继发于风湿性疾病的HLH，亦被称为“反应性噬血细胞综合征”。 目前已发现超过 30种系统性或器官特异性自身免疫性疾病和自身炎症性疾病与MAS 相关。

2024年4月16日 · Hemophagocytic lymphohistiocytosis (HLH) is a rare genetic hyperinflammatory syndrome that occurs early in life. Macrophage activation syndrome (MAS) usually refers to a secondary form of HLH associated with autoimmunity, although there are other causes of secondary HLH, such as infections and malignancy.

Macrophage activation syndrome (MAS) and hemophagocytic lymphohistiocytosis (HLH) are two overlapping, potentially fatal syndromes classified by disorganization and malfunction of the immune system that results in wide spread inflammation and end-organ damage .

Haemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening systemic hyperinflammatory syndromes characterised by fever, elevated ferritin and other markers of systemic inflammation, inappropriately low blood cell counts, disseminated intravascular coagulopathy, hepatitis, central nervous system (CNS) ...

Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome of excessive immune activation. It most frequently affects infants from birth to 18 months of age, but the disease is also observed in children and adults of all ages.

Introduction: Secondary haemophagocytic lymphohistiocytosis (sHLH) or Macrophage Activation Syndrome (MAS) is a life-threatening hyperinflammatory syndrome that can occur in patients with severe infections, malignancy or autoimmune diseases. It is also a rare complication of haematopoetic stem cell transplantation (HSCT), with a high mortality.

主要组织相容性复合体 （MHC）是一组编码细胞表面蛋白，用于细胞间识别和 抗原识别和抗原呈递，呈现高度多态性，在人类称为 HLA复合体 （人类白细胞抗原）。 HLA复合体定位第6号染色体断臂，长度约3.6Mb。 其中确认了 224个基因座位，其中128个位功能性基因，40%与免疫功能相关。 HLA复合体中很多基因座位的DNA序列在人群中存在许多变异体，即 HLA含大量的等位基因。 每一个体所具有的HLA等位基因及其产物均存在差异。 除同卵双胞胎外人群中几乎找不 …

2020年4月15日 · Macrophage activation syndrome (MAS), or secondary hemophagocytic lymphohistiocytosis (HLH), is a cytokine storm syndrome associated with multi-organ system dysfunction and...

1 天前 · The expansion of cycling lymphocytes correlates with disease activity and helps to distinguish HLH / MAS from clinical mimics. We demonstrate an approach to quantify CD38 + HLA-DR + cycling lymphocytes and evaluate their utility as a diagnostic biomarker for HLH / MAS. Lastly, we discuss the treatment of MAS, including potential therapeutic ...