Growth rate is an independent risk factor for lung cancer in screened pulmonary nodules. This study aimed to clarify growth characteristics of pulmonary nodules in routine clinical practice and examine whether volume doubling time (VDT) can predict the malignancy of these nodules.

Three-dimensional semiautomatic segmentation of nodules was performed to calculate the volume doubling time (VDT), mass doubling time (MDT), and specific growth rate (SGR) of volume and mass.

Calculating doubling time of focal lesions or massess can give a hint, whether it has a malignant or rather benign growth dynamics. Doubling time of malignant lesions is between 30 and 500 days with a median of 100 days. Diameter [mm] Volume [mm3] 1. Collins VP, Loeffler RK, Tivey H. Observations on growth rates of human tumors.

2023年11月1日 · For growing solid nodules, VDT was 204 days for malignant nodules and 386 days for benign nodules (P = 0.01); of these, VDT was <400 days for 12/13 (92%) of malignant nodules and 15/26 (58%) of benign nodules. In conclusion, malignant nodules were more likely to grow, and solid malignant nodules grew faster, than benign nodules.

摘要 目的比较伴或不伴基因突变的原发性肺腺癌在体积倍增时间 (volume doubling time,VDT)和质量倍增时间 (mass doubling time,MDT)间的差异。 方法选取2019年1月—2020年12月在同...

2014年6月14日 · To evaluate volume doubling time (VDT) and mass doubling time (MDT) of persistent pulmonary subsolid nodules (SSNs) followed-up with low-dose (LD) computed tomography (CT) in patients without a history of malignancy.

2024年5月13日 · Volume doubling time is defined as the time required for a growing nodule to double its volume. A longer VDT suggests a more benign course, whilst a short VDT is indicative of a more aggressive lesion with higher histological grade.

Purpose: To evaluate volume doubling time (VDT) and mass doubling time (MDT) of persistent pulmonary subsolid nodules (SSNs) followed-up with low-dose (LD) computed tomography (CT) in patients without a history of malignancy.

In the 44 patients with squamous cell carcinoma, the mean VDT was 133 days, and only 2.3% of these patients had a VDT of more than 400 days. These results were different from those previously reported for CT screening.

The volume doubling time (VDT) of a nodule, defined as the number of days in which the nodule doubles in volume, is a key parameter in lung cancer screening (1). Since 2000, a number of reports of VDT detected on chest computed tomography (CT) screening have been published (2 – …