2012年7月27日 · Mast cells (MCs) are constitutively present in most tissues and a distinct subset of MCs can also be induced upon host responses to inflammation. The hematopoietic lineage …

2015年1月1日 · Upon infections in the gut and in allergic inflammation in the lung, the local mast cell progenitor numbers increase tremendously. This review focuses on the origin and …

2001年7月1日 · The recognition that the mast cell-deficient mouse strains, termed W/W v and Sl/Sl d, have mutations in their membrane tyrosine kinase, c- kit, and its ligand, stem cell …

2018年8月15日 · Mast cells (MCs) are tissue-based stationary effector cells that form the immune system's first-line defense against various challenges. They are developed from the bone …

2011年11月23日 · Because the development of lineage progenitors and mature tissue MCs in vivo is crucially dependent on the binding of the growth factor stem cell factor to its receptor …

2022年5月24日 · This Perspective explores the divergent phenotypes and functions of mast cells resulting from both their hard-wired ‘nature’ defined by their ontogeny and the ‘nurture’ they …

4 天之前 · Mast cells (MCs) play a critical role in allergic inflammation, anaphylaxis, and chronic inflammatory diseases such as asthma, COPD, and osteoarthritis. Dysregulated MC activation …

2023年5月3日 · Mast cells are important cells of the hematopoietic lineage and play a crucial role in regulating the immune system, causing allergy and autoimmunity

Abstract Mast cells (MCs) play a critical role in allergic inflammation, anaphylaxis, and chronic inflammatory diseases such as asthma, COPD, and osteoarthritis. Dysregulated MC activation …

Here, we show that the GBS hemolytic pigment/lipid toxin and hyperpigmented GBS strains induce mast cell degranulation, leading to the release of preformed and proinflammatory …