The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a G protein–coupled receptor that binds to a class of pituitary peptide hormones known as the melanocortins, which include adrenocorticotropic hormone (ACTH) and the different ...

The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic gene, and loss of function correlates with a fair, UV-sensitive, and ...

2024年12月25日 · MC1R (Melanocortin 1 Receptor) is a Protein Coding gene. Diseases associated with MC1R include Skin/Hair/Eye Pigmentation, Variation In, 2 and Melanoma, Cutaneous Malignant 5. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

2022年2月1日 · Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color

In this review, we focus on the melanocortin 1 receptor (MC1R), a G protein-coupled receptor primarily known for regulating skin pigmentation and exhibiting anti-inflammatory effects. First, we provide an overview of the structure, signaling pathways, and related diseases of MC1R.

The Melanocortin 1 Receptor (MC1R) is a type of G protein-coupled receptor that responds to α-melanocyte-stimulating hormone (α-MSH) and adrenocorticotropic hormone (ACTH). Activation of MC1R leads to increased production of tyrosinase and the production of brown/black eumelanin.

Melanocortin 1 receptor remains the best characterized genetic determinant of human skin and hair pigmentation as well as the more firmly validated low penetrance skin cancer susceptibility gene. (Review) the nine most common MC1R variants make a sizeable contribution to the burden of melanoma (Meta-analysis)

One was identified as an alpha-MSH receptor, otherwise known as the melanocortin-1 (MC1) receptor (Mountjoy et al., 1992; Chhajlani and Wikberg, 1992). Because of the potential immunogenicity of the MC1R gene, Lopez et al. (2007) evaluated its …

2016年10月9日 · Title: A Side-by-Side Comparison of Wildtype and Variant Melanocortin 1 Receptor Signaling with Emphasis on Protection against Oxidative Damage to DNA. Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell …

2025年2月8日 · Melanocortin 1 receptor signaling is regulated by GRK2 and GRK6, which may be important determinants of skin pigmentation. UV-induced expression of POMC and MC1R is dependent on the p-38-activated upstream stimulating factor-1; the melanocortin-1 receptor (Mc1r) gene mediates kappa-opioid analgesia in female mice only