A commonly used mouse model of AD has been developed using the topical application of a low-calcemic analog of vitamin D3, MC903, to induce AD-like inflammatory phenotypes that …

Among various AD mouse models, AD-like inflammation induced by topical calcipotriol, a vitamin D3 analog referred to as MC903 in experimental settings, is a versatile model that can be …

Apr 6, 2017 · Here we report that MyD88 signaling is crucial in the pathogenesis of experimental AD induced by vitamin D3 analog MC903. The clinical signs and inflammation caused by …

The vitamin D3 analogue MC903, a psoriasis therapeutic drug, was used to induce AD-like symptoms in wild-type (WT) and JNK1-/- mice. The symptoms of AD were less severe in JNK1 …

Mar 13, 2023 · A commonly used mouse model of AD has been developed using the topical application of a low-calcemic analog of vitamin D3, MC903, to induce AD-like inflammatory …

Topical application of vitamin D3 or of its low-calcemic analog MC903 induces changes in skin morphology and inflammation resembling immune perturbations observed in acute lesions of …

Apr 20, 2020 · Topically applying MC903 (calcipotriol) on mouse skin has been reported to capture key features associated with AD. In the current study, we conducted a comprehensive …

Jun 1, 2024 · The molecular mechanism of MC903-induced AD in mice is relatively well understood. MC903 triggers a series of type 2 immune responses by inducing TSLP …

MC903 is a vitamin D3 analog which, when topically applied to mouse skin, induces inflammatory cellular infiltration, Th2-dominated cytokine responses, scaling, and erythema analogous to …

Jul 5, 2022 · Both CD4 + T cells and IL-33 are essential for chronic MC903-induced inflammations. MC903 skin inflammation model is one of well-characterized murine models of …