2022年11月1日 · Phellopterin improves MC903 induced AD-like symptoms including reduction of epidermal thickness, scales and serum IgE levels. Phellopterin reduces infiltration of eosinophils and mast cells in the AD-like skin lesions, and represses expression of …

2025年2月1日 · In this study, we showed that SE-EVs suppressed proinflammatory genes, promoted epidermal cell renewal, and induced β-defensins in MC903-treated HaCaT cells. In the MC903-induced dermatitis mouse model, SE-EVs diminished inflammatory cell infiltration and induced accumulation of IL17A + CD8 + T cells. Our results pointed toward the role of SE ...

2019年9月1日 · In this study, the anti-inflammatory mechanisms of Quercetin (Que) on atopic dermatitis (AD)-like skin lesions was examined. The left ear of mice was applied with MC903, followed by Que. administration daily on the ear for 8 days. Then macroscopic and histologic examination was performed to detect the severity of skin lesions.

2024年2月29日 · In this study, we investigated the protective effect of DMOG on MC903 (calcipotriol)-induced type 2 skin inflammation. Morphological and immunological changes were assessed by H-E staining, flow cytometry and RT-qPCR. DMOG treatment attenuated MC903-induced skin inflammation in a T cell-independent manner.

2023年3月23日 · 本研究表明，与溶解的se-evs相比，se-evs在mc903诱导的ad样皮肤炎小鼠和mc903处理的hacat细胞中具有更强的缓解炎症的能力。 这一结果得到了以下事实的支持：SE-EVs更易渗透皮肤并被靶细胞更有效地摄取。

We showed that SE-EVs significantly decreased the expression of proinflammatory genes (TNFα, IL1β, IL6, IL8, and iNOS) through lipoteichoic acid and increased the proliferation and migration of calcipotriene (MC903)-treated HaCaT keratinocytes.

MC903即 卡泊三醇，是一种维生素D3的低钙类似物，广泛用于治疗银屑病。 研究发现，局部使用MC903可激发小鼠上皮角质细胞高表达TSLP，促进CD4+T细胞向Th2细胞分化及激活并释放炎症细胞因子，引起小鼠产生特应性皮炎表型。 数据展示. 图2.使用克立硼罗软膏可明显降低MC903诱导的AD模型组小鼠皮肤厚度及疾病评分，以及细胞因子的水平。 恶唑酮（Oxazolone,OXA）与1,2,4-二硝基氟苯（1,2,4-Dinitrofluorobenzene, DNFB）等化合物属于半抗原，能与皮肤组织蛋 …

2024年10月2日 · MC903 treatment of the ear skin in Mettl3 cKO mice led to an increase in erythema and scaling that was accompanied by a significant increase in skin thickness, acanthosis, and dermal cell infiltration compared to WT mice (fig. S3, G to K).

2024年8月27日 · We aimed to evaluate the therapeutic effects and preliminary mechanisms of molybdenum nanoparticles (Mo NPs) by using a murine model of chemically induced AD-like disease. HaCaT cells, a spontaneously immortalized human keratinocyte cell line, were stimulated by tumor necrosis factor-alpha /interferon-gamma after pre-treatment with Mo NPs.

2023年7月17日 · In the presence of MC903, Tmem232-/- mice exhibited significantly reduced dermatitis severity, mast-cell infiltration in the back, and expression of T-helper (Th)1 and Th2-related inflammatory factors in skin tissue compared with wild-type mice.