CD4+ T cells play an essential role in chronic MC903-induced skin ...
2022年7月5日 · MC903 (calcipotriol) is an active vitamin D analog without affecting calcium metabolism [4] and has been used for psoriasis patients [5]. It induces irritant skin …
Intervening CCL8–CCR8 Signaling Reduces Cutaneous …
2025年1月4日 · MC903 (20 μl of 2 nmol in ethanol) was applied daily to the right cheek for 14 days, whereas the left cheek received ethanol as a control (Figure 1d). To evaluate the impact …
mTORC1 Deficiency Prevents the Development of MC903-Induced …
mTORC1 is essential for MC903-induced skin inflammation. (A) qPCR shows mRNA expression of Raptor after tamoxifen treatment. (B) The expression of pAkt and pS6 in the ear skin of WT …
CD4+ T cells play an essential role in chronic MC903-induced skin ...
2022年7月5日 · The expressions of IL-4 and IL-13 were investigated by qPCR and flow cytometry analysis using skin tissues. The expression of HO-1 was investigated by western blot and …
Frontiers | Prolyl hydroxylase inhibition protects against murine MC903 …
2024年2月29日 · In this study, we investigated the protective effect of DMOG on MC903 (calcipotriol)-induced type 2 skin inflammation. Morphological and immunological changes …
Ultraviolet-treated riboflavin alleviates atopic dermatitis by ...
2025年3月19日 · This study investigates the potential of ultraviolet (UV)-treated riboflavin in AD treatment. Using a MC903-induced mouse model, we demonstrate that topical UV-treated …
Heat shock protein 90 inhibition attenuates inflammation in
2024年1月11日 · Results: In primary human keratinocytes using RT-qPCR, the HSP90 inhibitor RGRN-305 strongly suppressed the gene expression of Th1- (TNF, IL1B, IL6) and Th2 …
Kaempferol therapy improved MC903 induced-atopic dermatitis …
The expressions of IL-4 and IL-13 were investigated by qPCR and flow cytometry analysis using skin tissues. The expression of HO-1 was investigated by western blot and qPCR. Results: …
Extracellular Vesicles of Commensal Skin Microbiota Alleviate …
2022年4月12日 · We showed that SE-EVs significantly decreased the expression of proinflammatory genes (TNFα, IL1β, IL6, IL8, and iNOS) through lipoteichoic acid and …
IL-18基因敲除可减轻MC903在小鼠模型中诱发的特应性皮炎样皮 …
2020年6月4日 · 进行RT-qPCR评估皮肤病变中IL-1β，IL-4，IL-9，STAT3，促肾上腺皮质激素释放激素受体（CRHR）1，CRHR2，TSLP和caspase-1的mRNA水平。 结果表明，IL-18可能 …
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