2020年12月14日 · Our previous reports showed that both human umbilical cord blood CD34 + cell- and human umbilical-cord-derived mesenchymal stem/stromal cell (MSC)-based therapies applied 48 h after permanent...

2016年1月13日 · Experiment 1 was to determine the best optimal timing of CD34+ cell treatment for the neuroprotective effect after 60-min middle cerebral artery occlusion (MCAO). Experiment 2 was to evaluate the adjuvant effect of 17β-estradiol on CD34+ cell neuroprotection after MCAO.

Our previous reports showed that both human umbilical cord blood CD34+ cell- and human umbilical-cord-derived mesenchymal stem/stromal cell (MSC)-based therapies applied 48 h after permanent...

2014年3月28日 · The intravenous administration of hUCB-CD34 +, but not CD34 − cells, ameliorates damage in adult mice with permanent MCAO (Taguchi et al., 2004a) and in a rat model of spinal cord injury (Kao et al., 2008).

2014年3月28日 · On postnatal day 12, immunocompromized (SCID) mice underwent permanent occlusion of the left middle cerebral artery (MCAO). Forty-eight hours after MCAO, human UCB CD34(+) cells (1×10(5)cells) were injected intravenously into the mice.

(a, d) Representative images of CD34-positive endothelial cells surrounding the contralateral cingulate in MCAO/r rats in the enriched environment (a) and standard cage groups (d).

In this study, we elucidated the metabolic changes that occur following neonatal MCAO using holistic analysis, and we visualized the distribution of glucose, carnitine glutamate and glutathione with MALDI-MS imaging. We also showed how two cell treatments (CD34 + cells and MSCs) affect the injured brain 72 h after MCAO. In the brain metabolic ...

2016年1月13日 · Experiment 1 was to determine the best optimal timing of CD34 + cell treatment for the neuroprotective effect after 60-min middle cerebral artery occlusion (MCAO). Experiment 2 was to evaluate the adjuvant effect of 17β-estradiol on CD34 + cell neuroprotection after MCAO.

The present study investigated the mechanism of ISO on vascular endothelial growth factor (VEGF) and CD34 expression in a rat model of stroke. Transient focal cerebral ischemia was established by middle cerebral artery occlusion (MCAO) for …

2018年1月15日 · The present results showed that transplantation of fresh human umbilical cord blood mononuclear cells (cbMNCs) attenuated ischemic damage in middle cerebral artery occlusion (MCAO) rats, accompanied with improvement of neurologic deficits, learning and memory function.