目的 探讨大鼠大脑中动脉缺血再灌注 (middle cerebral artery occlusion,MCAO)模型不同时期梗死区周围组织胶质纤维酸性蛋白 (glial fibrillary acidic protein,GFAP),神经元特异性烯醇化酶 (neuron-specific enolase,NSE),脑源性神经营养因子 (brain derived neurotrophic factor,BDNF),巢蛋白 …

2019年1月24日 · Low and high scale mapping of the glial activation on brain sections of mice subjected to 30 minutes middle cerebral artery occlusion (MCAO) was correlated with that of the neuronal cell death,...

To clarify neural mechanisms underlying ischemic stroke-evoked vasopressin hypersecretion, we observed the effect of unilateral permanent middle cerebral artery occlusion (MCAO) in rats on...

In contrast, the MCAO brain shows more abundant Cd11b+/GFP+ cells, which could correspond to penetrating periphery macrophages that express both markers. At day 7, both models show comparable immunoreactivity for Cd11b.

2017年6月22日 · Phagocytic astrocytes upregulate ABCA1 and its pathway molecules, MEGF10 and GULP1, which are required for phagocytosis, and upregulation of ABCA1 alone is sufficient for enhancement of...

Results: The hADSC-NCs survived well and transformed into MAP2-positive, Iba1- or GFAP-negative cells in vivo while maintaining some proliferative ability, indicated by positive Ki67 staining ...

Astrocytes become phagocytic after transient ischemic injury in vivo. a Representative images of the ischemic penumbra showing FJ-labeled and GFAP-immunostained brain sections at 7 days after MCAO (n = 10 mice). Arrowheads indicate FJ + -degenerating neuronal debris enwrapped by GFAP + astrocytes.

2020年3月24日 · In this study, we examined the neuroprotective effects of atorvastatin, cephalexin, and mycophenolate against the NF-κB in ischemic stroke, as compared to the standard NF-κB inhibitor caeffic acid phenethyl ester (CAPE).

Exposure to DA, MPP⁺, and MnCl2 upregulated glial fibrillary acidic protein (GFAP), a marker for astrocyte activation, and stimulated the levels of several astrocytic-derived factors.

目的: 探讨大鼠大脑中动脉缺血再灌注 (modified neurological severity scores,MCAO)不同时间梗死部位组织学和梗死面积,以及神经功能与凋亡调节蛋白,炎症及神经营养因子表达,神经及胶质细胞再生等变化在脑梗死中的关系及意义,以期为临床脑保护剂的应用提供实验依据.