2025年3月3日 · Reprogramming of glycometabolism plays a crucial role in the pathogenesis of cerebral ischemia–reperfusion injury (CIRI). Sestrin2 (SESN2), a sensor upstream of the mTORC1, is closely related to glycometabolism. However, the effect and mechanism of SESN2 in CIRI are unclear.

In brain, the facilitative diffusion glucose transporters GLUT1-6 and GLUT8, and the Na + - d -glucose cotransporters SGLT1 are expressed. The glucose transporters mediate uptake of d -glucose across the blood-brain barrier and delivery of d -glucose to astrocytes and neurons.

1998年7月15日 · Finally, these studies measure brain p44 and p88 in a rat middle cerebral artery occlusion (MCAO) model, as previous studies show MCAO results in an up-regulation of brain GLUT1 gene expression [13].

2019年1月11日 · The expression of glucose transporters (GLUTs) was examined by PCR and Western blot. Glucose uptake by microglia was inhibited using the GLUT1-specific inhibitor STF31. The metabolic profiles were tested using the Glycolysis Stress Test and Mito Stress Test Kits using the Seahorse XFe96 Analyser.

Increased GLUT1 expression in showed that MCAO and 2 h of reperfusion reduced 79.3% the number of astrocytes (GFAP positive cells) labeled for GLUT1 in the ipsilateral hemisphere of the...

2002年1月21日 · The aim of the present study was to investigate the role of the stabilizing GLUT1 CAE 2181−2190 in glucose deprivation and hypoxia using rat C6 stable transfected cell lines and site-directed deletion. Data presented here demonstrate that the GLUT1 CAE 2181−2190 mediates the increase of GLUT1 gene expression in glucose deprivation and hypoxia.

It was also shown that the expression levels of glucose transporter (GLUT)1 and GLUT3 were reduced in the MCAO group. However, following curcumin treatment, the levels of GLUT1 and GLUT3 were markedly increased. In addition, curcumin markedly decreased cell apoptosis, indicating an anti‑apoptotic role of curcumin in the brain.

2181–2190 of the GLUT1 3¢-untranslated region (CAE2181)2190), increases the expression of a GLUT1-luciferase reporter gene and decreases its mRNA decay. The present study investigated the role of the GLUT1 CAE2181)2190 in glucose deprivation and hypoxia using stable transfectants. Glucose and O2 deprivation

2024年7月11日 · Our results demonstrated that CK had a good affinity for GLUT1, which increased the expression of GLUT1 and the production of ATP, facilitated the proliferation and migration of MSCs, and activated the HIF-1α/VEGF signaling pathway to …

2022年1月15日 · Glucose transported to the brain is metabolized to lactate in astrocytes and supplied to neuronal cells via a monocarboxylic acid transporter (MCT). Lactate is used in neuronal cells for various functions, including learning and memory formation. Furthermore, lactate can block stroke-induced neurodegeneration.