Immune pathway activation in neurons triggers neural damage …
2023年11月28日 · In this study, using a unilateral mid-cerebral artery occlusion (MCAO) adult mouse stroke model, we performed high-throughput single-cell transcriptomic analyses, which …
Spatio-temporal overview of neuroinflammation in an ... - Nature
2019年1月24日 · Low and high scale mapping of the glial activation on brain sections of mice subjected to 30 minutes middle cerebral artery occlusion (MCAO) was correlated with that of …
Functional coupling of TRPM2 and extrasynaptic NMDARs …
Neuron-specific Trpm2 deletion was achieved by crossing nestin-cre mice with Trpm2fl/fl mice, which was confirmed by PCR, western blot (WB), and current recording (Figures S1 A–S1K). …
Frontiers | Eriodictyol Attenuates MCAO-Induced Brain Injury and ...
2021年5月25日 · Statistical analysis showed that compared with MCAO group, neuron loss was significantly reduced in the treatment group. To examine the effect of eriodictyol on the …
Transient middle cerebral artery occlusion induces microglial …
2008年7月7日 · Middle cerebral artery occlusion (MCAo) in mice results in a brain infarct, the volume of which depends on the length of occlusion. Following permanent occlusion, …
Lipocalin-2-mediated astrocyte pyroptosis promotes …
2023年6月23日 · LCN2 expression was significantly induced in astrocytes 24 h after stroke onset in the mouse MCAO model. Lcn2 knockout (Lcn2−/−) mice exhibited reduced infarct volume …
Transplantation of a bone marrow mesenchymal stem cell line …
2018年10月8日 · Mesenchymal stem cell (MSC) transplantation is demonstrated to improve functional and pathological recovery in cerebral ischemia. To understand the underlying …
GSK-3β inhibition elicits a neuroprotection by restoring lysosomal ...
2022年3月1日 · The result showed that GSK-3β inhibition-induced neuroprotection was greatly counteracted by lysosomal suppression in MCAO + CHIR + Baf-A1 group, compared with that …
Genome Med︱南京大学徐运课题组揭示缺血性卒中相关小胶质细 …
本研究采用大脑中动脉阻塞模型（middle cerebral artery occlusion，MCAO），并于造模后3小时、12小时和3天分别取MCAO小鼠的缺血半球进行单细胞转录组测序，最终确定了脑缺血后急 …
Lactate Supply from Astrocytes to Neurons and its Role in …
2022年1月15日 · Glucose transported to the brain is metabolized to lactate in astrocytes and supplied to neuronal cells via a monocarboxylic acid transporter (MCT). Lactate is used in …