2020年1月15日 · Progranulin (PGRN) is a secreted glycoprotein with pleiotropic functions. In the present study, we found that PGRN expression was markedly reduced in mice after stroke onset through middle cerebral artery occlusion (MCAO). We also showed that necroptosis was a mechanism underlying cerebral I/R injury.

2018年8月30日 · 该系统通过红细胞膜上“别吃我”信号分子CD47减少网状内皮系统的清除，增强了免疫逃逸能力，延长体内循环时间，在SHp缺血归巢肽作用下靶向缺血损伤区域，继而在ROS刺激响应下快速释放NR2B9C而修复神经元。

2023年5月2日 · Following stroke, oxidative stress induced by reactive oxygen species (ROS) aggravates neuronal damage and enlarges ischemic penumbra, which is devastating to stroke patients. Nanozyme-based antioxidants are emerging to treat stroke through scavenging excessive ROS.

RAPA@BMHOP降解产物能够有效地清除了MCAO小鼠手术损伤后的脑组织过氧化物积累，改善了炎症水平与脑部梗死体积。 研究结果表明，RAPA@BMHOP有望作为一种改善脑中风缺血再灌

2003年12月15日 · This study used an in vivo ESR spectroscopy/spin probe technique to measure directly the generation of reactive oxygen species (ROS) in the brain after cerebral ischemia-reperfusion. Transient middle cerebral artery occlusion (MCAO) was induced in rats by inserting a nylon thread into the internal carotid artery for 1 h.

2023年4月20日 · Schematic diagram of preparation of neutrophil targeting and ROS-responsive ligustrazine nanoparticles (T-TMP) and its neuroprotective mechanism on cerebral ischemia-reperfusion injury in middle cerebral artery occlusion (MCAO) model mice.

In barbiturate-anesthetized rats, we induced 3 hours of permanent middle cerebral artery occlusion (MCAO) by an intraluminal thread (n = 6), or 1 hour MCAO followed by 2 hours of reperfusion (n = 6). Through a closed cranial window over the parietal cortex, the production of reactive oxygen species …

2024年3月8日 · 研究了rHF纳米粒子在H 2 O 2诱导的PC12细胞中的ROS清除能力和对氧化损伤的保护作用。 通过短暂大脑中动脉闭塞（MCAO）再灌注小鼠模型研究 rHF 对缺血性卒中的治疗效果和神经保护机制。

通过荧光成像分析的体内分布证明 SPNPs 快速且增强地主动靶向 MCAO 大鼠缺血区域。 鼻内给药的 SPNPs 通过缓解氧化应激、减少炎症、修复线粒体功能和减少细胞凋亡表现出卓越的治疗效果。

2023年11月14日 · The ROS scavenging ability and protection effects against oxidative damage of rHF nanoparticles were studied in H 2 O 2 -induced PC12 cells. Therapeutic effects and neuroprotective mechanisms of rHF against ischemic stroke were investigated with transient middle cerebral artery occlusion (MCAO) reperfusion mice model.