Infarct volume and inflammation are reduced in mice treated intracerebroventricularly with recombinant human VEGF (0.02 µg/day) for 3–21 days before being subjected to 90 min of MCAO (248).

2003年6月6日 · Vascular endothelial growth factor (VEGF) is an angiogenic protein with therapeutic potential in ischemic disorders, including stroke. VEGF confers neuroprotection and promotes neurogenesis and cerebral angiogenesis, but the manner in which these effects may interact in the ischemic brain is poorly understood.

VEGF mRNA began to be upregulated in the peripheral ischemic area at 3 h after middle cerebral artery occlusion (MCAO) in rats, reached a peak at 24 h and remained at a lower level until 7 days after MCAO. Double labelling experiments have shown that microglia/macrophages are the main cell types that express VEGF [9].

2021年7月1日 · To test the involvement of VEGF signaling on malignant infarction in nonobese mice, lean mice were subjected to MCAO for a longer duration (40 minutes). This occlusion time increased infarct size, brain edema, and VEGFR2 mRNA expression (Figure 6A and 6B).

2012年5月1日 · Focal cerebral ischemia/reperfusion was induced by the middle cerebral artery occlusion (MCAO) method. In a dose response experiment, low (1.25 ng/μL), middle (2.5 ng/μL) and high (5.0 ng/μL) doses of VEGF were administered 2 h …

VEGF expression is initially detectable 6 hours after MCAO in the pia overlying the infarct region ( arrows in B ), and in scattered glia-like cells in the infarct region of the cortex ...

In a rat model of transient focal ischemia induced by middle cerebral artery occlusion (MCAO), VEGF (1–3 days after ischemia) exerts multiple effects, such as neuroprotection, neurogenesis in the dentate gyrus and the subventricular zone, and …

2017年5月15日 · Vascular endothelial growth factor (VEGF) is considered to have protective effects against stroke. VEGF was shown to participate in neuronal survival, increase microvascular density, and promote glial proliferation and migration after cerebral ischemia (Sanchez et al., 2010).

Vascular endothelial growth factor (VEGF) is an endothelial cell specific mitogen that has been implicated in hypoxia-mediated angiogenesis under physiological and pathological conditions. We used the middle cerebral artery occlusion model (MCAO) in the rat to investigate VEGF mRNA and protein local …

2015年11月5日 · RT-PCR and western blot revealed that galangin protected NVUs through the Wnt/β-catenin pathway coupled with HIF-1α and vascular endothelial growth factor (VEGF). VEGF and β-catenin could be...