Von Willebrand factor (VWF), a multimeric glycoprotein, has long been implicated in ischemic stroke pathology 2, 3. ... MCAO/R was performed by introducing a silicone-coated monofilament to transiently occlude the MCA (see Supplemental Methods). The monofilament occluder was in place for 30 min and reperfusion allowed for 120 min. Relative ...

2022年11月3日 · von Willebrand factor (VWF) is a large sialoglycoprotein that circulates in normal plasma as a series of heterogeneous multimers 1,2.For many years, the importance of plasma VWF in maintaining ...

2022年3月10日 · Significant restoration of rCBF and reduced lesion volume was observed in animals treated with caADAMTS13. When administered 1 hour after FeCl3 MCAo, the caADAMTS13 variant significantly reduced residual VWF and fibrin deposits in the MCA, platelet aggregate formation, and neutrophil recruitment.

(MCAO). At day 3 after MCAO and reperfusion, we found an in-crease in 18F-FDG uptake in the aorta (Figure 1C), ... Cluster 1 highly expressed Vcam1, Vwf, and other genes such as Cytl1 and Clu (Figures 1G and 1H). Cluster 2 ex-pressed genes involved in lipid transport, including Cd36, Fabp4, and Rgcc (Figures 1G and 1H). Cluster 3 expressed ...

2016年10月26日 · von Willebrand factor (VWF) is an ultra-large multimeric glycoprotein, which is present in Weibel-Palade bodies of endothelial cells and alpha granules of platelets and is released in circulation ...

2003年6月15日 · vWF immunohistochemistry in DG and caudate-putamen (CPu) from control rats (Con) and 1 week after MCAO (Isch) or MCAO plus VEGF treatment (Isch + VEGF). For the latter two groups, fields shown are from the ischemic hemisphere.

2006年10月12日 · When animals were cotreated with the angiogenesis inhibitor endostatin for 14 days starting 1 day after MCAo, the effect of running on BrdUrd + and vWF-associated BrdUrd + cells was completely abrogated (Figure 5A and 5B). vWF immunostaining demonstrated largely increased endothelial cell densities within ischemic tissue of running compared ...

我们发现，TSP4-BMSC输注可促进中风后神经功能的恢复。经tsp4基因修饰的骨髓间充质干细胞比野生型骨髓间充质干细胞具有更好的治疗效果。TSP4-BMSC输注改善了MCAO大鼠的神经功能评分，并扩大了脑缺血半影中von Willebrand因子（vWF），Ang-1，MMP2和MMP9蛋白的表达。

Introduction: We demonstrated that VWF inhibition thrombolyses stabilized clots in and decreases infarct size after middle cerebral artery occlusion (MCAO) in pre-clinical models of stroke. Objective: To compare the thrombolytic efficacy of von Willebrand Factor (VWF) inhibition by DTRI-031 versus rTPA and aspirin utilizing an ex vivo Halo assay. Hypothesis: We hypothesized that DTRI-031 ...

2022年3月10日 · When administered 1 hour after FeCl 3 MCAo, the caADAMTS13 variant significantly reduced residual VWF and fibrin deposits in the MCA, platelet aggregate formation, and neutrophil recruitment. When administered 4 hours after reperfusion in the tMCAo model, the caADAMTS13 variant induced a significant dissolution of platelet aggregates and a ...