A computational perspective for tailor-made selective Mcl-1 and Bcl …
Apr 5, 2022 · In view of the crucial role of Mcl-1 in tumor survival and resistance as well as the importance of Bcl-XL in platelets homeostasis, an appropriate tuning of binding selectivity …
Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055
Jan 2, 2023 · We, therefore, aimed to develop an effective and safe strategy targeting these anti-apoptotic proteins with DT2216 (our platelet-sparing BCL-X L degrader) and AZD8055 (an …
MCL-1 抑制剂与 BCL-2/BCL-XL 或 MAPK 通路抑制剂的协同作用增 …
急性髓系白血病 (aml) 是一种血液系统恶性肿瘤，其特征是异常髓系前体细胞过度增殖，并伴有分化阻滞和细胞凋亡抑制。抗凋亡 mcl-1 蛋白的表达增加被证明对 aml 细胞的持续存活和扩增至 …
The identification of BCL-XL and MCL-1 as key anti-apoptotic
Oct 28, 2023 · Collectively, our study identifies that BCL-XL and MCL-1 are the key anti-apoptotic proteins in medulloblastoma, which mediate distinct protective roles. While BCL-XL has a first …
Mcl-1 and Bcl-xL are essential for survival of the developing
Oct 25, 2018 · We used Nestin-mediated, nervous system-specific conditional deletion of mcl-1, bcl-x or both to identify their distinct and overlapping roles. Individual conditional deletion of …
Mcl-1 和 Bcl-xL 在多阶段调节巨核细胞谱系的 Bak/Bax 依赖性细胞 …
ABT-737 是一种 Bcl-xL/Bcl-2/Bcl-w 抑制剂，仅在成年野生型小鼠中引起血小板减少症，但在 Mcl-1 敲除小鼠中进一步诱导大量成熟巨核细胞凋亡，导致严重的出血性贫血。 如果下游细胞凋亡 …
Mcl-1 and Bcl-xL cooperatively maintain integrity of ... - PubMed
Mcl-1 and Bcl-xL are two major anti-apoptotic Bcl-2 family proteins expressed in the liver and cooperatively control hepatic integrity during liver development and in adult liver homeostasis …
The identification of BCL-XL and MCL-1 as key anti-apoptotic
Oct 28, 2023 · Collectively, our study identifies that BCL-XL and MCL-1 are the key anti-apoptotic proteins in medulloblastoma, which mediate distinct protective roles. While BCL-XL has a first …
Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts ... - PubMed
In multiple myeloma cell lines (n = 21), BCL-2 is expressed but sensitivity to venetoclax correlated with high BCL-2 and low BCL-XL or MCL-1 expression. Multiple myeloma cells that coexpress …
Targeting MCL-1 in cancer: current status and perspectives
Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins. Overexpression of MCL-1 is …