2024年12月25日 · MCM6 (Minichromosome Maintenance Complex Component 6) is a Protein Coding gene. Diseases associated with MCM6 include Lactose Intolerance, Adult Type and Fructose And Galactose Intolerance. Among its related pathways are Activation of the pre-replicative complex and CDK-mediated phosphorylation and removal of Cdc6.

最近的一项研究报道，mcm6可能是诊断肝细胞癌的一种新的生物标志物和潜在的hcc分子靶点，特别是在中国南方壮族人群中。在肺癌中，mcm6是预后不良的重要标志，与ki-67相关。 mcm6除了可以作为多种肿瘤预后和诊断的标志物外，还可以作为治疗靶点。

MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The MCM complex consisting of MCM6 (this protein) and MCM2, 4 and 7 possesses DNA helicase activity, and may act as a DNA unwinding enzyme.

MCM6 promotes intrahepatic cholangiocarcinoma progression by upregulating E2F1 and enhancing epithelial-mesenchymal transition. MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target.

2022年9月6日 · MCM6 knockdown suppressed proliferation and migration of GC cells and patient-derived organoids, and attenuated xenograft growth and peritoneal metastasis in mice. Mechanistically, MCM6 activated PI3K/Akt/GSK3β signaling to support YAP-potentiated gastric tumorigenicity and metastasis.

MCM6 is a significant DNA replication regulator that plays a crucial role in sustaining the cell cycle. In many cancer cells, MCM6 expression is enhanced. For example, persistently increased expression of MCM6 promotes the formation, development and progression of hepatocellular carcinoma (HCC).

2005年9月27日 · Multivariate analysis revealed MCM6 to be an independent predictor of survival that is superior to the international prognostic factor and the Ki-67 index. Therefore, aside from gene expression...

mcm6作为家族成员之一，具有调节细胞周期和促进dna复制等功能，在维持基因组正常复制中扮演着关键的角色。在消化系统恶性肿瘤中，mcm6的表达水平异常增高，且与部分疾病的不良预后密切相关。其作为肿瘤诊疗的生物标志物具有极大的潜力。

The MCM6 gene provides instructions for making a protein that is part of the MCM complex, a group of proteins that functions as a helicase. Helicases attach to particular regions of DNA and temporarily unwind the two spiral strands of these molecules.

2021年6月1日 · MCM6 is a significant DNA replication regulator that plays a crucial role in sustaining the cell cycle. In many cancer cells, MCM6 expression is enhanced. For example, persistently increased expression of MCM6 promotes the formation, development and progression of hepatocellular carcinoma (HCC).