The Anti-Melanoma (MCSP) antibody recognizes the melanoma-associated chondroitin sulfate proteoglycan (MCSP) antigen, also known as high molecular weight melanoma-associated antigen. MCSP is expressed on the majority (>90%) of human melanoma tissues and melanoma cell lines but not on carcinoma cells, fibroblastoid cells, and cells of ...

Assessment of microsatellite instability and tumor mutational burden status. This test uses targeted next-generation sequencing to estimate tumor mutational burden and detect microsatellite instability, sequence variants, gene amplifications, homozygous gene deletions, fusions, and specific transcript variants in solid tumors.

2010年11月23日 · Anti-MCSP:TRAIL was designed to 1. selectively accrete at the cell surface of MCSP-positive melanoma cells and inhibit MCSP tumorigenic signaling and 2. activate apoptotic TRAIL-signaling. Results: Treatment of a panel of MCSP-positive melanoma cell lines with anti-MCSP:TRAIL induced TRAIL-mediated apoptotic cell death within 16 h.

2010年11月23日 · Treatment of a panel of MCSP-positive melanoma cell lines with anti-MCSP:TRAIL induced TRAIL-mediated apoptotic cell death within 16 h. Of note, treatment with anti-MCSP:sTRAIL was also characterized by a rapid dephosphorylation of key proteins, such as FAK, implicated in MCSP-mediated malignant behavior.

MCSP 是黑色素瘤免疫治疗的成熟靶点，最近已被证明可以为黑色素瘤细胞提供重要的致瘤信号。 TRAIL 是一种非常有前途的杀肿瘤细胞因子，对正常细胞没有毒性或毒性很小。 Anti-MCSP:TRAIL 旨在 1. 选择性地在 MCSP 阳性黑色素瘤细胞的细胞表面增殖并抑制 MCSP 致瘤信号，以及 2. 激活凋亡 TRAIL 信号。 结果 用抗 MCSP:TRAIL 处理一组 MCSP 阳性黑色素瘤细胞系在 16 小时内诱导了 TRAIL 介导的细胞凋亡。 值得注意的是，用抗 MCSP:sTRAIL 治疗的特征还在于关键 …

2020年8月19日 · The dual‐utilization OncoBean (DUO) device is conjugated with melanoma specific antibodies, MCAM and MCSP, enabling simultaneous CTC and exosome isolations. Using blood samples from patients, CTCs and exosomes are specifically isolated from a single sample and then undergo molecular profiling for comprehensive study.

We first screened JWCI's panel of 35 melanoma cell lines to determine the level of MCSP surface expression. MCSP-negative and MCSP-positive cell lines were used to determine the antigen specificity of redirected lysis by MCSP-BiTE.

The dual-utilization OncoBean (DUO) device is conjugated with melanoma specific antibodies, MCAM and MCSP, enabling simultaneous CTC and exosome isolations.

2009年5月15日 · Melanoma-associated chondroitin sulfate proteoglycan (MCSP) (also known as high molecular weight-melanoma-associated antigen) represents an interesting target antigen for cancer immunotherapy which is expressed on human melanomas and other tumors such as breast carcinomas, gliomas, neuroblastomas an …

2010年11月23日 · MCSP is a well-established target for melanoma immunotherapy and has recently been shown to provide important tumorigenic signals to melanoma cells. TRAIL is a highly promising tumoricidal...