
二氰基吡嗪(DPZ)在光氧化还原催化中的新进展,Photochem - X …
二氰基吡嗪 (DPZ) 是一种研究相对较少的有机光氧化还原催化剂,通过其在有机合成中的催化活性显示出巨大的潜力,需要合成界的关注。 可见光有机光氧化还原催化已成为有机合成转化的宝贵工具,因为它与有机底物协同工作,并且已知为有机转化创造独特的化学环境。 二氰基吡嗪 (DPZ) 是一种研究相对较少的有机光氧化还原催化剂,通过其在有机合成中的催化活性显示出巨大的潜力,需要合成界的关注。
Dicyanopyrazine-derived push–pull chromophores for highly …
Here, we report dicyanopyrazine (DPZ)-derived push–pull chromophores, easily prepared and tunable organic compounds, as new kinds of photoredox catalysts.
化学前沿 | 河南大学江智勇课题组Angew. 可见光不对称催化反应新 …
2017年10月17日 · 本文中他们使用自主发展的DPZ作为可见光催化剂,并通过使用手性胍的四氟硼酸盐作为添加剂,成功发展了可见光诱导的高立体选择性的1,2-二酮不对称还原反应。 随后,他们将该催化体系拓展到α-羰基酮亚胺的不对称还原中,取得了良好的产率和立体选择性。 该研究首次将不对称质子化概念引入可见光不对称催化中,对于可见光催化的不对称反应具有重要的指导意义。 平台声明:该文观点仅代表作者本人,搜狐号系信息发布平台,搜狐仅提供信息存储空间 …
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Comparative Study of Donepezil-Loaded Formulations for the …
Cholinergic deficit has been reported to be the major pathological cause for AD. In this case, the use of some acetylcholinesterase (AChE) inhibitors including galantamine, risvastigmine, and donepezil hydrochloride (DPZ) have been used to improve cholinergic function.
河南师范大学江智勇/尹艳丽团队Nat. Commun.:催化不对称 [4
2024年6月2日 · 该研究通过光敏剂和手性Brønsted酸协同催化平台,实现了三重态DPZ与蒽及衍生物之间的能量转移,从而启动精确且立体选择性的序列转化,最终获得了对映体富集且具有广泛底物范围的环加成产物。
Construction and Characterization of Thermosensitive Hydrogel …
多奈哌齐 (DPZ) 是一种可逆的胆碱酯酶抑制剂,用于治疗阿尔茨海默病 (AD),但具有口服后胃肠道副作用和老年人依从性差等缺点。本研究的目的是开发一种载有多奈哌齐纳米混悬剂 (DPZ-NS-gel) 的热敏水凝胶,用于经鼻给药,以改善脑靶向并降低外周毒性。
Formulation, Preparation, Characterization, and Evaluation of ...
DPZ is an acetylcholinesterase inhibitor used to treat cognitive symptoms in mild to moderate AD [3,4,5]. In particular, it appears to benefit both cognitive ability and mental function [4,5]. DPZ, 2-[(1-benzyl-4-piperidyl) methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one, is a piperidine-based agent that is chemically unique among all ChEIs.
Combining donepezil and memantine via mannosylated PLGA
2023年10月16日 · The current work is focused on developing mannose-coated PLGA nanoparticles for delivering Donepezil and Memantine in one dosage form. The formulated nanoparticles were prepared using a simple emulsification technique. The final coated NPs exhibited 179.4 nm size and - 33.1 mV zeta potential and spherical shape.
Optimized method development and validation for determining …
2024年9月6日 · Donepezil (DPZ), a piperidine-based reversible cholinesterase inhibitor, finds extensive use in treating Alzheimer’s disease (AD). Originally designed as an oral formulation, DPZ encounters drawbacks such as a brief duration of action and reduced treatment effectiveness in elderly patients with memory impairment or difficulty swallowing ...