2024年11月22日 · We aimed to perform conventional MDS simulations to evaluate potential changes in ligand-binding affinity for structural and catalytic NADP + and the glucose-6-phosphate (G6P) substrate. During the MDS calculations, the G6PD complexes were first relaxed and subsequently clustered with a hierarchical analysis, which assessed highly existent ...

2022年9月28日 · G6PD overexpression in Drosophila Melanogaster and mice protects against metabolic stress, oxidative damage, and age-associated functional decline, and results in an extended median lifespan. This review discusses whether the well-known positive effects of exercise training in skeletal muscle are mediated through an increase in G6PD. 1.

Glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme in the pentose phosphate pathway which produces nicotinamide adenine dinucleotide phosphate (NADPH) to maintain an adequate reducing environment in the cells and is …

2023年7月20日 · During the epidemiological surveillance of RVA in the Northwest Amazon region, an unusual rotavirus genotype G6P[8] was detected in feces of a 2-year-old child with acute gastroenteritis (AGE) that had been vaccinated with one dose of Rotarix® (RV1).

Glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme in the pentose phosphate pathway which produces nicotinamide adenine dinucleotide phosphate (NADPH) to maintain an adequate reducing environment in the cells and is especially ...

The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase (G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in cells. NADPH also plays key roles in cellular processes mediated by redox ...

2023年8月11日 · Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an erythro-enzymopathy that has been recognized as the most common cause—through an X-linked hereditary genetic defect due to mutations in the G6PD gene—of CNSHA, which affects nearly 500 million people worldwide. G6PD deficiency leads to a defect in the PPP in red blood cells [ 5 ].

Several studies have shown enhanced G6PD expression and PPP flux in various tumor cells, as well as their correlation with tumor progression through cancer hallmark regulation, especially reprogramming cellular metabolism, sustaining proliferative signaling, resisting cell death, and activating invasion and metastasis.

2022年12月17日 · Glucose-6-phosphate dehydrogenases (G6PDHs) are cytosolic or plastidial enzymes that catalyze the oxidation of glucose-6-phosphate (G6P) to 6-phosphogluconolactone. Their activity diverts part of G6P from glycolysis to the oxidative pentose phosphate pathway (OPPP), so that it is key for determining the balance between these two metabolic pathways.

Several studies have shown enhanced G6PD expression and PPP flux in various tumor cells, as well as their correlation with tumor progression through cancer hallmark regulation, especially reprogramming cellular metabolism, sustaining proliferative signaling, resisting cell death, and activating invasion and metastasis.