Here, we will review the characteristics of the mdr1a -/- model of spontaneous colitis that we believe make this model an important part of the IBD researcher's toolbox. We will also share new data that will reinforce the fact that this model is relevant in the study of IBD.

1998年11月15日 · The intestinal inflammation seen in mdr1a −/− mice has a pathology similar to that of human inflammatory bowel disease (IBD) and is defined by dysregulated epithelial cell growth and leukocytic infiltration into the lamina propria of the large intestine.

In mice, loss of MDR1 function results in colitis with similarities to human inflammatory bowel diseases (IBD). Here, we show that MDR1 has an unexpected protective role for the mitochondria where MDR1-deficiency results in mitochondrial dysfunction with increased mitochondrial ROS (mROS) driving the development of colitis.

Here, we will review the characteristics of the mdr1a −/− model of spontaneous colitis that we believe make this model an important part of the IBD researcher's toolbox. We will also share new data that will reinforce the fact that this model is relevant in the study of IBD.

2025年2月6日 · The Mdr1a knockout (KO) mouse model is increasingly used in IBD research due to its ability to mimic human colitis through microbiome-driven inflammation and a compromised immune barrier, providing valuable insights into disease mechanisms and potential treatments.

2004年1月2日 · Panwala等发现将mdr1a基因敲除（mdr1a-/-）的小鼠置于无特异性病原体（SPF）环境下，可诱导出与人类溃疡性结肠炎（UC）类似的模型[Panwala CM , Jones JC , Viney JL .A Novel Model of Inflammatory Bowel Disease: Mice Deficient for the Multiple Drug Resistance Gene, mdr1a, Spontaneously Develop Colitis.J ...

2013年10月1日 · This study tested the anti-inflammatory potential of a green tea extract rich in polyphenols (GrTP) in the colon of the multidrug resistance targeted mutation (Mdr1a −/−) mouse model of IBD. Insights into mechanisms responsible for this reduction in inflammation were gained using transcriptome and proteome analyses.

Mdr1a knockout mice have a barrier defect that leads to spontaneous colitis in response to the enteric microbiota. Il10 knockout mice develop spontaneous colitis and

1998年11月15日 · The murine multiple drug resistance (mdr) gene, mdr1a, encodes a 170-kDa transmembrane protein that is expressed in many tissues including intestinal epithelial cells, a subset of lymphoid cells and hematopoietic cells. We report that mdr1a knockout (mdr1a-/-) mice are susceptible to developing a se …

In this review article, we briefly introduce 74 kinds of genetically engineered mouse models that spontaneously develop intestinal inflammation. Keywords: epithelial barrier, ER stress, knockout mice, IBD susceptibility gene, immunoregulation, mouse models.