2024年12月6日 · The average price for a property in ME2 2HG is £222,000 over the last year. Explore Rightmove house prices to find out how much properties sold for in ME2 2HG.

2022年2月28日 · Here we show that cancer-associated mutant p53 protein is stabilized by 2-hydroxyglutarate generated by malic enzyme 2. Mechanistically, malic enzyme 2 promotes the production of 2-hydroxyglutarate...

Map of ME2 2HG postcode in Rochester, England with local information, lat/long: 51.394229, 0.479805, grid reference: TQ726690

2022年3月3日 · 在本项目研究工作中，研究人员发现在肿瘤细胞内，苹果酸酶2 (ME2)可以通过调控2-羟基戊二酸（2-HG）的合成而增加突变体p53的蛋白稳定性。 过表达ME2可以增加细胞内2-羟基戊二酸（2-HG）的产生，反之，敲低ME2则减少了细胞内2-HG的水平。 深入的机制探索发现，2-HG可以直接与突变体p53结合，通过减少Mdm2介导的mutp53的泛素化和降解，从而增强mutp53的蛋白稳定性；但对于野生型p53没有此功能。 有意思的是， ME2除了通过调整细胞 …

All about the ME2 2HG Postcode in Rochester: from latest house prices, broadband speeds, historical maps to top local attractions!

2022年2月28日，清华大学江鹏及中国医学科学院杜文静共同通讯在 Nature Metabolism 在线发表了题为“Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate”的研究论文，该研究证明了癌症相关突变体P53蛋白是由苹果酸酶2产生的2-羟基戊二酸稳定的。 从机制上讲，苹果酸酶2通过调节谷氨酰胺分解以及通过需要丙酮酸和NADPH的反应来促进2-羟基戊二酸的产生。 在体外和体内，苹果酸酶2的缺失降低了细胞内2-羟基戊二酸的水平，而苹果酸 …

View information about Clifton Close, Rochester, ME2 2HG postcode, including employment, safety, property prices, nearby schools, broadband, sport facilities, nearby restaurants and pubs.

The last sale in ME2 2HG went for £305,000 in April, 2024. 63% of property sold in this postcode are semi-detached houses. Get accurate up-to-date valuations.

65 Clifton Close, Rochester is a 3 bedroom freehold semi-detached house spread over 872 square feet, making it one of the bigger properties here - it is ranked as the 10th most expensive property* in ME2 2HG, with a valuation of £285,000.

Clifton Close Rochester ME2 2HG. Clifton Close is a Street in the town of Rochester with the postcode of ME2 2HG which measures approximately 433 metres long. Clifton Close is within the Post Town of ROCHESTER