2024年12月25日 · This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene.

2024年1月23日 · Here we report that activation of AKT1 induces a metabolic switch to glycolysis from the mitochondrial metabolism via phosphorylation of cytoplasmic malic enzyme 2 (ME2), named ME2fl (fl means...

2024年9月5日 · In mammalian cell, malic enzyme 2 (ME2), as the major isoform of malic enzymes in mitochondria, is important for cell senescence, lipogenesis, and proliferation of many tumor cells. 18,19,20,21,22 For instance, ME2 promotes acute myeloid leukemia progression through regulating mitobiogenesis, 18 and also promotes MYC-driven T cell lymphomagenesi...

2023年5月22日 · Human mitochondrial NAD (P) + -dependent malic enzyme (ME2) is well-known for its role in cell metabolism, which may be involved in cancer or epilepsy. We present...

2023年11月25日 · SIRT5 interacts with and desuccinylates ME2. As an important metabolic enzyme in mitochondria, ME2 catalyzes the oxidative decarboxylation of malic acid to yield pyruvate and is essential for...

NAD-dependent malic enzyme, mitochondrial is a protein that in humans is encoded by the ME2 gene. [4][5] This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate.

A reduction in cellular αKG levels triggered by malic enzyme 2 (ME2) or isocitrate dehydrogenase 1 (IDH1) depletion leads to a pronounced arrest in G1 phase, while αKG supplementation promotes cell-cycle progression.

2021年5月4日 · Here, we report that the Krebs cycle intermediate fumarate links metabolism to mitobiogenesis through binding to malic enzyme 2 (ME2). Mechanistically, fumarate binds ME2 with two complementary consequences. First, promoting the formation of ME2 dimers, which activate deoxyuridine 5'-triphosphate nucleotidohydrolase (DUT).

This gene encodes a mitochondrial NAD-dependent malic Enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene.

2024年8月16日 · 在2022年发表于Nature Metabolism的研究工作发现苹果酸酶ME2通过调控细胞内2-羟基戊二酸 （2-HG） 的生成，维持突变体p53的蛋白稳定性，从而促进肿瘤细胞生长，该研究发现了ME2在细胞内的一种新的催化活性 （详见BioArt报道：）【2】。在2023年发表于PNAS的 …