Gestational diabetes mellitus (GDM) is a serious pregnancy complication, in which women without previously diagnosed diabetes develop chronic hyperglycemia during gestation. In most cases, this hyperglycemia is the result of impaired glucose tolerance due to pancreatic β-cell dysfunction on a background of chronic insulin resistance.

The subtype gestational diabetes mellitus (GDM) occurs during pregnancy, which severely affects both the mother and the growing foetus. Obesity, uncontrolled weight gain and advanced gestational age are the prominent risk factors for GDM, which lead to high rate of perinatal mortality and morbidity.

2019年11月5日 · Two major metabolic disorders, chronic insulin resistance and β-cell dysfunction, are currently linked to the pathogenesis of GDM, although the cellular mechanisms involved are not yet completely understood.

Gestational Diabetes Mellitus (GDM) is a highly prevalent maternal pathology characterized by maternal glucose intolerance during pregnancy that is, associated with severe complications for both mother and offspring. Several risk factors have been related to GDM; one of the most important among them is genetic predisposition.

Gestational diabetes mellitus (GDM) is the most common metabolic disturbance during pregnancy. The prevalence is rising and correlates with the increase in maternal obesity over recent decades. The etiology of GDM is complex, with genetic and environmental factors implicated in mechanistic and epide …

2023年6月1日 · Gestational diabetes mellitus (GDM) is a medical complication of glycaemic intolerance that develops in 2nd or 3 rd trimester of pregnancy. The speculative cause behind insulin resistance or chronic glycemic intolerance occurs due to pancreatic β-cell alterations during gestation.

2018年10月26日 · Gestational diabetes mellitus (GDM) is a serious pregnancy complication, in which women without previously diagnosed diabetes develop chronic hyperglycemia during gestation. In most cases, this hyperglycemia is the result of impaired glucose tolerance due to pancreatic β-cell dysfunction on a background of chronic insulin resistance.

2018年10月26日 · Gestational diabetes mellitus (GDM) is a serious pregnancy complication, in which women without previously diagnosed diabetes develop chronic hyperglycemia during gestation. In most cases, this hyperglycemia is the result of impaired glucose tolerance due to pancreatic β-cell dysfunction on a background of chronic insulin resistance.

2018年6月28日 · Gestational diabetes mellitus (GDM) is the most common metabolic distur-bance during pregnancy. The prevalence is rising and correlates with the increase in maternal obesity over recent decades. The etiology of GDM is complex, with genetic and environmental factors implicated in mechanistic and epidemiological studies.

With advances in omics technology, analyses of metabolic organs, including maternal adipose tissue, liver tissue, placental tissue, and fetal umbilical cord blood (CB), have been attempted to clarify the underlying pathophysiological mechanisms for maternal and …