2024年12月25日 · MEIS1 (Meis Homeobox 1) is a Protein Coding gene. Diseases associated with MEIS1 include Restless Legs Syndrome and Restless Legs Syndrome 7. Among its related pathways are RNA Polymerase I Promoter Opening and Nervous system development.

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene. [5][6] Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in …

2023年7月27日 · We identify the transcription factor Meis1 as an essential regulator of hemogenic cell specification in the embryo prior to Runx1 expression. Meis1 is expressed at the earliest stages of EHT...

2013年4月17日 · Here we identify Meis1 as a critical regulator of the cardiomyocyte cell cycle. Meis1 deletion in mouse cardiomyocytes was sufficient for extension of the postnatal proliferative window of...

2022年7月1日 · Meis1 is a new target for the treatment of arrhythmia after myocardial infarction. The principal voltage-gated Na + channel, Na V 1.5 governs heart excitability and conduction. Na V 1.5 dysregulation is responsible for ventricular arrhythmias and subsequent sudden cardiac death (SCD) in post-infarct hearts.

2012年12月13日 · The role of Meis1 in leukemia is well established, but its role in hematopoietic stem cells (HSCs) remains poorly understood. Previously, we showed that HSCs use glycolytic metabolism to meet their energy demands. However, the mechanism of regulation of HSC metabolism, and the importance of maintain …

2025年2月19日 · The homeodomain transcription factor MEIS1 triggers chemokine expression and is involved in CD8+ T-lymphocyte infiltration in early stage ovarian cancer. Karapetsas A, et al. Mol Carcinog, 2018 Sep. PMID 29802738; Sleep disturbance by pramipexole is modified by Meis1 in mice. Salminen AV, et al. J Sleep Res, 2018 Aug. PMID 28695622

results reveal that MEIS1, through induction of SYTL1, promotes leukemogenesis and supports leukemic cell homing and engraftment, facilitating interactions between leukemic cells and bone marrow stroma. Meis1 regulates expression and activation of Syk in Hoxa9-driven leukemia.

2022年5月27日 · Myeloid ecotropic virus insertion site 1 (MEIS1) is essential for normal hematopoiesis and is a critical factor in the pathogenesis of a large subset...

2021年3月1日 · Recent research identified MEIS1 as an important transcription factor that regulates cell proliferation and differentiation during cell fate commitment. MEIS1 has a pro-proliferative effect in leukemia cells; however, its overexpression in cardiomyocytes restrains neonatal and adult cardiomyocyte proliferation.