
Defining Roles for HOX and MEIS1 Genes in Induction of Acute …
We have previously shown that HOXA9 collaborates with MEIS1 in the induction of acute myeloid leukemia (AML). In this report, we demonstrate that HOXB3, which is highly divergent from …
Persistent Transactivation by Meis1 Replaces Hox Function in …
Here we demonstrated that in the absence of coexpressed Hox genes, a dominant activating form of Meis1 (Vp16-Meis1) sustains self-renewal of undifferentiated hematopoietic progenitors that …
The HOX-MEIS connection in AML | Blood - American Society of …
2005年7月1日 · In this issue of Blood, Wang and colleagues have shed light on the molecular mechanisms whereby 2 homeobox genes—one oncogenic (Hoxa9) and one not (Meis1)—can …
Elucidating the importance and regulation of key enhancers for …
2022年5月27日 · Myeloid ecotropic virus insertion site 1 (MEIS1) is a HOX co-factor known to be necessary for normal hematopoiesis [1, 2] and it is implicated in a...
Defining roles for HOX and MEIS1 genes in induction of acute …
In this report, we demonstrate that HOXB3, which is highly divergent from HOXA9, also genetically interacts with MEIS1, but not with PBX1, in generating AML. In addition, we show …
Persistent transactivation by meis1 replaces hox function in …
Vp16-Meis1-mediated transformation required the Meis1 function of binding to Pbx and DNA but not its C-terminal domain (CTD). The absence of endogenous Hox gene expression in Vp16 …
The Hox cofactors Meis1 and Pbx act upstream of gata1 to …
2010年4月15日 · Pbx-depleted and meis1-morphant embryos exhibit normal posterior hox gene expression. Shown are representative embryos following in situ hybridization analyses of …
Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk ... - PubMed
2017年4月10日 · In the context of Hoxa9 overexpression, Syk signaling induces Meis1, recapitulating several leukemogenic features of Hoxa9/Meis1-driven leukemia. Finally, Syk …
Deregulation of the HOXA9/MEIS1 Axis in Acute Leukemia
In mammals the 39 class 1 homeobox, or HOX genes, are arranged into four parologous clusters (A, B, C and D) on separate chromosomes (3, 4). In addition to their role in regulating …
Clinical Significance of HOX and Meis gene Expression Profiling in ...
2024年11月5日 · The selective binding of HOX proteins to DNA is influenced by interactions with cofactors, most notably the MEIS family. While the regulation of HOX genes in certain AML …