We have previously shown that HOXA9 collaborates with MEIS1 in the induction of acute myeloid leukemia (AML). In this report, we demonstrate that HOXB3, which is highly divergent from …

Here we demonstrated that in the absence of coexpressed Hox genes, a dominant activating form of Meis1 (Vp16-Meis1) sustains self-renewal of undifferentiated hematopoietic progenitors that …

2005年7月1日 · In this issue of Blood, Wang and colleagues have shed light on the molecular mechanisms whereby 2 homeobox genes—one oncogenic (Hoxa9) and one not (Meis1)—can …

2022年5月27日 · Myeloid ecotropic virus insertion site 1 (MEIS1) is a HOX co-factor known to be necessary for normal hematopoiesis [1, 2] and it is implicated in a...

In this report, we demonstrate that HOXB3, which is highly divergent from HOXA9, also genetically interacts with MEIS1, but not with PBX1, in generating AML. In addition, we show …

Vp16-Meis1-mediated transformation required the Meis1 function of binding to Pbx and DNA but not its C-terminal domain (CTD). The absence of endogenous Hox gene expression in Vp16 …

2010年4月15日 · Pbx-depleted and meis1-morphant embryos exhibit normal posterior hox gene expression. Shown are representative embryos following in situ hybridization analyses of …

2017年4月10日 · In the context of Hoxa9 overexpression, Syk signaling induces Meis1, recapitulating several leukemogenic features of Hoxa9/Meis1-driven leukemia. Finally, Syk …

In mammals the 39 class 1 homeobox, or HOX genes, are arranged into four parologous clusters (A, B, C and D) on separate chromosomes (3, 4). In addition to their role in regulating …

2024年11月5日 · The selective binding of HOX proteins to DNA is influenced by interactions with cofactors, most notably the MEIS family. While the regulation of HOX genes in certain AML …