2017年1月5日 · In this study, we demonstrated that IL-1β induced the activation of p38, JNK and MEK/ERK1/2, and that the pharmacological inhibition of p38, JNK, MEK, and ERK1/2 completely attenuated IL-1β...

2021年7月21日 · 熟悉信号通路的童鞋们肯定知道Ras、Raf、MEK和ERK蛋白就是该通路中的关键因子，其中任何一个蛋白的功能异常都会导致严重的肿瘤疾病。 Ras/Raf/MEK/ERK信号转导途径：

2022年10月3日 · Mechanistic study showed that this MLN4924 effect is largely independent of neddylation inactivation, but is due to activation of both ERK and JNK signals, leading to AP-1 activation, which is...

The α 1-AdrR effect on JNK occurs through a pathway requiring Ras and MEK kinase (MEKK). A constitutively activated mutant of MEKK that preferentially activates JNK, stimulates ANF reporter gene expression, while a dominant negative MEKK …

我们已经研究了mekk3对mapk激酶7（mkk7）和mkk6的调节，这两种激酶分别对jnk和p38有特异性。 MKK7与MEKK3在COS-7细胞中的共表达增强了MKK7自磷酸化作用，并增强了其在体外激活重组JNK1的能力。

2013年4月12日 · Four distinct MAP kinase signaling pathways involving 7 MEK enzymes have been identified. MEK1 and MEK2 are the prototype members of MEK family proteins. Several MEK inhibitors are in clinical trials. Trametinib is being evaluated by FDA for the treatment of metastatic melanoma with BRAF V600 mutation.

2018年5月24日 · We show here that MEK inhibition activates JNK-JUN signaling through suppression of DUSP4, leading to activation of HER Receptor Tyrosine Kinases. This stimulates the MAPK pathway in the...

2017年1月5日 · These observations suggest that JNK1 phosphorylation is necessary for the activation of the MEK/ERK1/2 pathway and the subsequent COX-2 expression for PGE 2 release, and p38 independently contributes to the IL-1β effect in synovial fibroblasts.

Investigating the molecular basis of activation of the c-Jun N-terminal kinase (JNK) subgroup of MAPK by the MAPKKK MEKK2, we found that strong and specific JNK1 activation by MEKK2 was mediated by the MAPKK JNK kinase 2 (JNKK2) rather than by JNKK1 through formation of a tripartite complex consisting of MEKK2, JNKK2, and JNK1.

2013年8月27日 · jnk/sapk信号通路 可被应激刺激(如紫外线、热休克、高渗刺激及蛋白合成抑制剂等)、细胞因子(tnfα，il-1)、生长因子(egf)及某些g蛋白偶联的受体激活。