Mitogen-Activated Protein Kinase Kinase Kinase 2 also known as MEKK2 (MEK/ERK Kinase 2) is an enzyme that in humans is encoded by the MAP3K2 gene. [5] [6] [7]

mapk（丝裂原活化蛋白激酶）通路有三级的信号传递过程：mapk，mapk激酶（mek或mkk）以及mapk激酶的激酶（mekk或mkkk）。这三种激酶能依次激活，共同调节着细胞的生长、分化、应激、炎症反应等多种重要的生理/病理…

2020年11月11日 · Here, the authors report the MEKK2 is a key mediator of this aberrant ERK activation and that MEKK2 inhibitors, including ponatinib, ameliorate skeletal defects in a mouse model of NF1.

利用mekk2 ko小鼠，我们发现：1、细菌感染可以激活mekk2。2、ko小鼠对内毒素引起的感染性休克有缺陷。3、李斯特菌感染后，ko 巨噬细胞生成细胞因子较少。因此，mekk2可能在抗菌感染中起核心作用。

In this study, we showed that MEKK2 serves as a negative regulator of MPK4. It binds to MPK4 to directly inhibit its phosphorylation by upstream MKKs. Activation of SUMM2-mediated defense responses induces the expression of MEKK2, which in turn blocks MPK4 phosphorylation to further amplify immune responses mediated by SUMM2.

2018年4月17日 · Here we show that MEKK2 (MAP3K2) and MEKK3 (MAP3K3) inhibit GLI1 transcriptional activity and oncogenic function through phosphorylation on multiple Ser/Thr sites of GLI1, which reduces GLI1 ...

2023年5月19日 · Best3-MEKK2/3 signaling represents a novel therapeutic target for AD. These findings unveil a critical role of Best3 in regulating smooth muscle cell phenotypic switch and aortic structural integrity through controlling MEKK2/3 degradation.

2017年12月19日 · 内容提示： 上海交通大学医学院 2013 级博士研究生学位论文 mekk2 和 和 mekk3 在炎症 与 血管 发育 中的 功能及机制研究 作者姓名：邓汉强 学 号：0137109043 指导教师：苏 冰 教授 专 业：免疫学 申请学位：博 士 培养单位：基础医学院 研究方向：mapk 信号通路调 …

2020年4月8日 · Disruption of this kinase cascade leads to activation of SUMM2-mediated immune responses. MEKK2, a close paralog of MEKK1, is required for defense responses mediated by SUMM2, the molecular mechanism of which is unclear. In this study, we showed that MEKK2 serves as a negative regulator of MPK4.

2016年3月1日 · The ability of MEKK2 to increase β-catenin levels resulted from posttranslational regulation of β-catenin stability, because β-catenin transcript levels were not altered by the absence of MEKK2 (Fig. S3D), and the low β-catenin levels in Mekk2 −/− COBs could be rescued by blocking proteasomal degradation of β-catenin with the ...