Multiple endocrine neoplasia, type 2, also called MEN 2, is a rare condition. It causes tumors in the thyroid and parathyroid glands, adrenal glands, lips, mouth, eyes and digestive tract. Genetic testing can find the changed gene that causes MEN 2 .

MEN2 is a sub-type of MEN (multiple endocrine neoplasia) and itself has sub-types, as discussed below. Variants in MEN2A have been associated with Hirschsprung disease. Screening for this condition can begin as young as eight years old for pheochromocytoma.

2022年2月25日 · Multiple endocrine neoplasia, type 2A (MEN 2A) is an autosomal dominant syndrome characterized by medullary carcinoma of the thyroid, pheochromocytoma, parathyroid hyperplasia or adenomas (causing hyperparathyroidism), and occasionally cutaneous lichen …

2023年8月14日 · Multiple endocrine neoplasia type 2 (MEN 2) is a hereditary cancer syndrome associated primarily with tumors of the adrenal gland, thyroid and parathyroid. It is further classified into MEN2A and MEN2B.

Multiple endocrine neoplasia type 2A (MEN 2A) is is an inherited disorder caused by genetic changes in the RET gene. Individuals with MEN 2A are at high risk of developing medullary carcinoma of the thyroid.

2025年1月14日 · There are two types of MEN2: MEN 2A and MEN 2B. It is important for your doctor to know the exact change you have in the RET gene to know your risk for getting the diseases in MEN2. If you are diagnosed with either form of MEN2, you will need life-long monitoring by an endocrinologist.

Three types of multiple endocrine neoplasia (MEN) syndromes are most common: MEN type 1, MEN type 2A and MEN type 2B. MEN syndromes are caused by genetic changes; therefore, they tend to run in the families. Symptoms of MEN are different based on the type of the disease and the glands involved.

2022年5月23日 · Multiple endocrine neoplasia (MEN) type 1: This is a genetic condition in which multiple tumors affect different aspects of your endocrine system. Multiple endocrine neoplasia type 2 (MEN2) : This is a genetic polyglandular (multiple glands) cancer syndrome.

1999年9月27日 · Decker RA, Peacock ML, Watson P. Hirschsprung disease in MEN 2A: increased spectrum of RET exon 10 genotypes and strong genotype-phenotype correlation. Hum Mol Genet. 1998;7:129-34. [ PubMed : 9384613 ]

2024年5月13日 · Multiple Endocrine Neoplasia Type 2A (MEN2A) The signs and symptom of MEN2A may include: Medullary thyroid carcinoma (MTC), present in almost all the cases of MEN2A, a form of aggressive cancer that spreads easily and arises from thyroid cells called C cells (parafollicular cells), which produce the hormone calcitonin that helps with the ...