2017年1月17日 · The liver injury due to the meropenem is usually mild and self-limited. Rarely, meropenem and other carbapenems can cause a clinically apparent and protracted cholestatic hepatitis that is usually self-limiting, but can lead to vanishing bile duct syndrome.

This case demonstrates that meropenem can cause severe liver injury and that early recognition of drug-induced liver injury is important. Keywords: infections, hepatitis other, toxicology, unwanted effects/adverse reactions.

A drug-induced liver injury was suspected and meropenem was discontinued. Following discontinuation of meropenem, the patient demonstrated symptomatic and laboratory improvements, and her liver enzymes and bilirubin levels were normalized.

This case demonstrates that meropenem can cause severe liver injury and that early recognition of drug-induced liver injury is important. A 63-year-old man admitted to hospital for the management of a frontal lobe abscess developed elevated liver enzymes within 48 hours of receiving meropenem.

2021年1月26日 · This report describes what we believe is the first reported case of clinically significant cholestasis and acute liver injury within three days of meropenem therapy. An 83-year-old Hispanic female was admitted for sepsis of unknown …

2021年1月2日 · This report describes what we believe is the first reported case of clinically significant cholestasis and acute liver injury within three days of meropenem therapy.

2024年8月6日 · Tazobactam/piperacillin and meropenem are commonly used as an empiric treatment in patients with severe bacterial infections. However, few studies have investigated the cause of tazobactam/piperacillin- or meropenem-induced liver injury in them.

2017年1月17日 · Meropenem is a common cause of mild transient aminotransferase elevations and can rarely result in clinically apparent, cholestatic liver injury. Meropenem is a carbapenem antibiotic with broad spectrum of activity that is administered intravenously and used for severe bacterial infections due to sensitive agents.

In summary, the current treatment practice of nSBP with meropenem provides early effective drug levels in plasma and ascites without reaching toxic concentrations.

Numerous drugs, both prescription and over-the-counter, herbal products, or toxins can cause hepatotoxicity through a variety of mechanisms. A high index of suspicion is often necessary to expeditiously establish the diagnosis.