2022年2月15日 · Heterochromatin protein 1 (HP1) governs heterochromatin organization through maintaining protein stability and chromatin binding of H3K9 methyltransferases and demethylases in mESCs. HP1 interaction‐defective H3K9 MTs undergo protein degradation. HP1 depletion reduces H3K9 MTs and H3K9 DMs protein levels.

Multiple proteins, including members of the heterochromatin protein 1 (HP1) family, bind H3K9me2/3 and are involved in transcriptional silencing in model organisms. In this work, we address the role of such H3K9me2/3 "readers" in the silencing of ERVs in mESCs.

2018年4月23日 · Studies in mouse embryonic stem cells (mESCs) have suggested that multiple H3K9me3 modifiers, such as Suv39h1/h2 and ERG-associated protein with SET domain (ESET) complexes, are responsible for...

In mouse embryonic stem cells (mESCs), transcriptional silencing of numerous class I and II endogenous retroviruses (ERVs), including IAP, ETn and MMERVK10C, is dependent upon the H3K9 methyltransferase (KMTase) SETDB1/ESET and its binding partner KAP1/TRIM28.

2022年6月2日，清华大学郗乔然和北京师范大学王占新共同通讯在Cell Stem Cell 在线发表题为“A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells”的研究论文，该研究发现 TRIM66 和 DAX1 一起作为 mESC 中 2C 样状态的负调节因子。

2022年11月15日 · Nanobody-mediated recruitment of endogenous full-length HP1 family members (Cbx1, Cbx3, and Cbx5) to chromatin allowed potent gene silencing, but repression was dependent on affinity and the ...

2013年6月4日 · Background: In mouse embryonic stem cells (mESCs), transcriptional silencing of numerous class I and II endogenous retroviruses (ERVs), including IAP, ETn and MMERVK10C, is dependent upon the H3K9 methyltransferase (KMTase) SETDB1/ESET and …

2019年5月8日 · HP1 is relocalized in part at telomeres where it further stimulates SETDB1 recruitment and increases H3K9me3 formation. We found that this excessive heterochromatin stimulates ALT-associated PML body formation, TERRA transcription, and the recruitment of recombination factors.

2022年2月15日 · Heterochromatin protein 1 (HP1) specifically recognizes H3K9me2/3, contributing to transcriptional suppression and spread of H3K9me2/3. Here, we demonstrate another...

2022年2月15日 · Here, we show another crucial role of HP1 in mammalian hete-rochromatin organization: HP1 regulates protein stability of H3K9 MTs. In the absence of HP1, Suv39h1/2, Setdb1, and G9a/GLP complexes were significantly reduced at the protein level.