2018年1月8日 · Cross-linkable gelatin methacryloyl (GM) is widely used for the generation of artificial extracellular matrix (ECM) in tissue engineering. However, the quantification of modified groups in GM is still an unsolved issue, although this is the key factor for tailoring the physicochemical material prope …

2024年3月1日 · Improving the degree of methacryloyl substitution or gelatin concentration can accelerate the gelation process and reinforce the mechanical properties. The micellar cross-links dramatically improved the thermal stability of gelatin hydrogel.

In this contribution, 1 H– 13 C-HSQC NMR spectra are used to gain detailed structural information on GMs and of 2-fold modified gelatin containing methacryloyl and acetyl groups (GMAs). Distinctive identification of methacrylate, methacrylamide, and acetyl groups present in GMs and GMAs revealed an overlap of methacrylamide and modified ...

2019年5月3日 · GelMA can be prepared through simple synthesis of gelatin with methacrylic anhydride (MAA), and its methacryloyl functionalization (or the degree of substitution (DS); the degree of ...

2020年4月9日 · Herein, a new green synthetic approach for the methacryloyl hyaluronic acid preparation with a tailorable substitution degree (SD) is reported, in which methacryloyl hydrazide is used as a more reactive reagent and only water is used as the solvent.

2023年7月1日 · By adjusting the degree of substitution, concentration of GelMA or initiator, and UV exposure time, the stiffness of GelMA hydrogels is tailorable in a wide range (from <1 to 30 kPa) for affecting various cell behaviors [31].

2019年4月7日 · This study demonstrates the synthesis of CSMA with a varying degree of substitution (DS) to generate hydrogels with varying swelling properties, maximum injection force, and drug release kinetics. The DS of the synthesized CSMA ranged from 0.05 ± 0.02 (2 h reaction) to 0.28 ± 0.02 (24 h reaction) with a DS of 1 representing 100% modification.

2023年4月28日 · In this study, a uniform standard is established to understand and enhance GelMA applications. First, the basic concept of GelMA and the density of the molecular network (DMN) are defined. Second, two properties, degrees of substitution and ratio of solid content, as the main measurable parameters determining the DMN are used.

2007年3月23日 · This paper reports on the synthesis of methacrylate derivatized HyA with precise control over the substitution degree in a suitable aprotic solvent by substitution of the parent polysaccharide with glycidyl methacrylate.

2023年11月3日 · The degree of methacryloyl substitution of fabricated GelMA was about 60%, giving the GelMA a wide range of controllable stiffness. Single dissociated CPCs were then embedded into the 5% (w/v) GelMA gels cross-linked with different concentrations of HA and RGD to determine the appropriate combinations for CPC growth.