2020年12月1日 · Here, we investigate the potential of 18 F-mFBG, a positron emission tomography (PET) analogue of the 123 I-mIBG radiotracer, to quantify NET-1 expression levels in mouse models of NB following...

2022年11月26日 · Recently, [18 F]MFBG has emerged as a promising PET alternative. This prospective trial aimed to evaluate safety, biodistribution, tumour lesion pharmacokinetics, and lesion targeting of [18 F]MFBG and perform a head-to-head comparison with [123 I]MIBG in neural crest tumour patients.

2022年11月16日 · 在病理情况下，神经内分泌来源的恶性肿瘤，例如嗜铬细胞瘤高表达NET。 而MFBG是一种去甲肾上腺素胍乙啶类似物，可被高表达NET的嗜铬细胞瘤及其转移灶的肿瘤细胞所摄取并停留在细胞质中。

进行去甲肾上腺素转运蛋白 (NET)显像剂 18 F－间氟苄胍 (mFBG)的自动化合成，并研究其对嗜铬细胞瘤的显像效果。 根据mFBG化学结构，设计并合成作为标记前体的叔丁氧羰基保护的金刚烷螺环间碘叶立德苄胍1 (1种高价碘叶立德)，在AllinOne自动化模块上完成 18 F标记、脱保护、中和三步反应，经高效液相色谱 (HPLC)分离纯化，制剂化后得 18 F－mFBG产品，再进行质量控制检测。 对1例嗜铬细胞瘤术后患者 (男，30岁)行 18 F－mFBG PET/CT显像。

We developed improved methods for the synthesis of known MIBG analogs, [ (18)F]MFBG and [ (18)F]PFBG and evaluated them in hNET reporter gene-transduced C6 rat glioma cells and xenografts. Methods: [ (18)F]MFBG and [ (18)F]PFBG were synthesized manually using a three-step synthetic scheme.

123 I-间碘苄胍（123 I-MIBG）是去甲肾上腺素类似物，能够与去甲肾上腺素转运蛋白特异性结合，可用于神经内分泌肿瘤SPECT显像、心脏交感神经SPECT显像及帕金森病的头部显像。 但 123 I-MIBG的不足之处限制了其临床应用，国内外研究者的多项研究结果表明 18 F-间氟苄胍（18 F-MFBG）是最有望代替 123 I-MIBG的显像剂。 笔者就 18 F-MFBG的制备及临床应用进展进行综述。

We conducted a first-in-human study of 18 F-MFBG PET imaging to evaluate the safety, feasibility, pharmacokinetics, and dosimetry of 18 F-MFBG in neuroendocrine tumors (NETs).

2022年12月12日 · Meta - [18 F]fluorobenzylguanidine ( [18 F]mFBG) is a positron emission tomography (PET) radiotracer that allows for fast and high-resolution imaging of tumours expressing the norepinephrine transporter. This pilot study investigates the feasibility of [18 F]mFBG PET-CT for imaging in neuroblastoma.

2017年7月12日 · the diaryliodonium salt (ALP)-MFBG precursor, supplied by Ground Fluor Pharmaceuticals, Inc. (Cambridge, MA). The revised synthesis, derived from the methods published in (17), involved nucleophilic incorporation of 18F-fluoride into the 18F-MFBG precursor, ALP-MFBG (7.5 mg dissolved in 1 mL of

Positron-emitting F-18 meta-fluorobenzylguanidine (MFBG) has recently been developed for potentially superior quantitative characterization. We assessed the feasibility of MFBG imaging of myocardial sympathetic innervation.