2022年4月29日 · Utilizing several genetic mouse models, high resolution imaging, and transcriptomic profiling, we show that Mfn1 and 2 act in tandem to preserve β-cell mitochondrial health and, consequently,...

2025年2月10日 · Restoring MFN2 levels re-establishes proteostasis in MFN2-KO cells and rescues fusion defects of MFN1-KO cells. In contrast, MFN1 loss or mitochondrial shape alterations do not alter protein...

2023年1月12日 · Here we report a small molecule agonist, S89, that specifically promotes mitochondrial fusion by targeting endogenous MFN1. S89 interacts directly with a loop region in the helix bundle 2 domain...

We show that mitochondrial dynamics mediated by Mitofusin 1 (MFN1) in POMC neurons couple nutrient sensing with systemic glucose metabolism. Mice lacking MFN1 in POMC neurons exhibited defective mitochondrial architecture remodeling and attenuated hypothalamic gene expression programs during the fast-to-fed transition.

MFN1 KO disturbs the P13K-AKT pathway and interaction with other somatic cells, thus blocking folliculogenesis and oocyte growth (Carvalho et al., 2020). A study on the role of MFN1 in oocyte development shows that oocyte-specific knockout of mitofusin 1 causes female mice infertility related to abnormal folliculogenesis and oocyte quality.

2014年11月11日 · In response to glucose starvation, mitofusin 1 (MFN1) becomes associated with the protein deacetylase HDAC6. This interaction leads to MFN1 deacetylation and activation, promoting mitochondrial fusion. Deficiency in HDAC6 or MFN1 prevents mitochondrial fusion induced by glucose deprivation.

2025年3月4日 · Mitochondrial fusion occurs through the mediation of.by MFN1, MFN2, and optic atrophy protein 1 (OPA1), and mitochondrial fission is mediated by Drp1 ... and Fgf13 knockout mice and Fgf13 plus Prkn double KO mice and induced with HFD/STZ, found that Fgf13 deficiency could be important for the regulation of mitochondrial ...

Mfn1 and 2 single KO cells (mouse embryonic fibroblasts) were transfected with wild type DLP1 and immunostained for DLP1 and cytochrome c for mitochondrial morphology. Mitochondria became...

Mechanism and regulation of mitochondrial dynamics. Mitochondrial fusion (upper left panel) is mediated by large dynamin-related GTPase proteins Mfn1, Mfn2, and OPA1. Mitochondrial outer membrane (MOM) fusion is mediated by Mfn1 and Mfn2, whereas mitochondrial inner membrane (MIM) fusion is mediated by OPA1.

2022年7月7日 · While both MFN1 and MFN2 deficient cells display a clearly fragmented mitochondrial network, MFN1 knockout cells display severe mitochondrial fragmentation with the formation of small spheres...