Mitofusin 2 displays fusion-independent roles in proteostasis ...
2025年2月10日 · Restoring MFN2 levels re-establishes proteostasis in MFN2-KO cells and rescues fusion defects of MFN1-KO cells. In contrast, MFN1 loss or mitochondrial shape …
Mitofusin 2: from functions to disease | Cell Death & Disease
2018年2月28日 · MFN2, an outer mitochondrial membrane GTPase, is critical for mitochondrial fusion, which in turn affects mitochondrial dynamics, distribution, quality control, and function. …
Mitofusin 1 and 2 regulation of mitochondrial DNA content is a
2022年4月29日 · Utilizing several genetic mouse models, high resolution imaging, and transcriptomic profiling, we show that Mfn1 and 2 act in tandem to preserve β-cell …
MFN2 coordinates mitochondria motility with α-tubulin …
2024年6月21日 · By combining our observations in Mfn2 KO MEFs and KD sensory neurons, we propose that axonal degeneration caused by MFN2 loss of function mutations may not depend …
Mitofusin-2 modulates the epithelial to mesenchymal transition …
2021年1月21日 · MFN2 expression was significantly correlated with cell adhesion molecules and epithelial to mesenchymal transition (EMT) in a gene-set enrichment assay. MFN2 knock-out …
The role of Mfn2 in the structure and function of endoplasmic …
2021年7月7日 · To better understand the role of Mfn2 in MERCs in neurons in vivo, we characterized MERCs in the pyramidal neurons of hippocampi in Mfn2 conditional knockout …
Cell | 非酒精性脂肪肝病或找到新靶点——线粒体与内质网协作失败 …
线粒体融合蛋白2 （Mitofusion2, Mfn2）是在MAMs结构里起到物理连接作用的蛋白之一， 研究表明线粒体外膜和内质网膜上的两个Mitofusin2分子可以形成二聚体从而将两者距离拉近 【8】 …
Mitofusin 2: from functions to disease - PMC - PubMed Central …
MFN2, an outer mitochondrial membrane GTPase, is critical for mitochondrial fusion, which in turn affects mitochondrial dynamics, distribution, quality control, and function. MFN2 modulates …
Mitofusin2 (MFN2) Preserves Mitochondrial Integrity and Function …
2021年11月23日 · Using platelet/megakaryocyte specific Mfn2-/-(Mfn2 KO) mice, we show that Mfn2 impacts platelet numbers, activation and function by regulating mitochondrial energetics. …
Mitofusin 2: A link between mitochondrial function and substrate ...
2021年11月1日 · Mitofusin 2 (Mfn2), an outer mitochondrial membrane fusion protein specializes in mediating mitochondrial homeostasis. Early studies defined the biological significance of …