Beta-1,3-N-acetylglucosaminyltransferase manic fringe is an enzyme that in humans is encoded by the MFNG gene, [5][6][7] a member of the fringe gene family which also includes the radical fringe (RFNG) and lunatic fringe (LFNG). [8][9]

2024年12月25日 · MFNG (MFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Diseases associated with MFNG include Large Cell Acanthoma and Gummatous Syphilis. Among its related pathways are Pre-NOTCH Expression and Processing and Development Notch Signaling Pathway.

The MFNG (MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase) is a protein-coding gene located on chromosome 22. The MFNG gene encodes a protein called beta-1,3-N-acetylglucosaminyltransferase manic fringe. This enzyme belongs to the fringe gene family, which includes radical fringe (RFNG) and lunatic fringe (LFNG).

Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extrac ellular domain of Notch molecules (By similarity).

2024年8月4日 · Clinical resource with information about MFNG, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. The RNA data was used to cluster genes according to their expression across cell lines.

2024年8月17日 · MFNG is an independent prognostic marker for osteosarcoma. Nuclear and stromal expression of Manic fringe in renal cell carcinoma. MFNG imposes a negative correlation between Jag1 and Notch, being high Jag1 in the absence of MFNG predictive of poor prognosis. Mfng is an oncogene acting through Notch-mediated induction of Pik3cg.

Lunatic, Manic and Radical Fringe (LFNG, MFNG and RFNG) are N-acetylglucosaminyltransferases that modify Notch receptors and regulate Notch signaling. Loss of LFNG affects thymic T cell development and LFNG and MFNG are required for marginal zone (MZ) B cell development.

Fringe is a glycosyltransferase involved in tumor occurrence and metastasis. However, a comprehensive analysis of the Fringe family members lunatic fringe (LFNG), manic fringe (MFNG), radical fringe (RFNG) in human cancers is lacking.

Patients with elevated MFNG expression had a worse prognosis, according to the survival analysis. It was unveiled by the univariate and multivariate analyses that MFNG expression was an independent adverse prognostic factor for disease-free survival in OS patients (p = 0.006).