2021年8月4日 · MFSD2A is a blood–brain-barrier-specific lipid transporter and a key inhibitor of transcytosis 6, 7, 11. Mice that lack the lipid transport function of MFSD2A have...

2016年2月1日 · Mfsd2a is the first inhibitor of the transcytosis and the first transporter for lysophosphatidylcholine-docosahexaenoic acid (LPC-DHA) in BMECs. The crucial dual …

2022年6月16日 · Brain development and function require uptake of essential omega-3 fatty acids in the form of lysophosphatidylcholine via major-facilitator superfamily transporter MFSD2A, a …

Wnt signaling directly controls the transcription of an endothelium-specific transcytosis inhibitor, major facilitator superfamily domain–containing protein 2a (MFSD2A), in a β …

2021年7月6日 · Here, we show that cerebrovascular EC-specific deletion of Pten (phosphatase and tensin homolog) results in a dramatic increase in vesicular transcytosis by the reduction of …

2024年9月1日 · Inhibition of Mfsd2a is associated with a reduction in tight junction proteins expression and augmentation in endothelial cell transcytosis. The Blood-Labyrinth Barrier …

Mfsd2a deficient, Cav1 deficient, and Mfsd2a EC-specific inducible mice were developed to study the underlying molecular mechanisms. We demonstrated that inhibiting Wnt signaling by …

Mfsd2a has attracted more and more attention in the study of nervous system diseases because of its critical role in maintaining the integrity of the blood-brain barrier (BBB) and transporting …

Our structure of MFSD2A in an outward-facing conformation provides a blueprint for structure-based discovery of MFSD2A inhibitors. In addition, biologics, such as an extracellular surface …

2020年8月28日 · Wnt signaling directly controls the transcription of an endothelium-specific transcytosis inhibitor, major facilitator superfamily domain-containing protein 2a (MFSD2A), in …