MG7 antigen expression is highly specific in gastric cancer and can be used as a good marker for screening of gastric cancer; type III intestinal metaplasia, atrophic gastritis and dysplasia should be followed up and MG7 antigen expression has high …

2015年3月3日 · MG7-Ag, a specific gastric cancer-associated antigen, can be used to non-invasively monitor gastric cancer by molecular imaging with positron emission tomography/computed tomography (PET/CT).

1 天前 · The efficacy of the system was confirmed using the model antigen OVA and the gastric cancer-specific antigen MG7-related peptide. The results demonstrated that the nanovaccine effectively activated the immune response, leading to enhanced recognition and response to the antigens. This activation of both TLR9 and cGAS-STING pathways in antigen ...

In this study, the monoclonal antibody MG7, which is a specific molecular marker against gastric cancer, was labeled with fluorescent agents to enable in vivo real-time imaging by confocal laser endomicroscopy (CLE).

人胃癌MG7抗原(MG7-Ag)是一种中性糖脂类肿瘤相关抗原,其在正常胃黏膜中不表达或低表达,而在早期胃癌中的特异性高表达让其有可能成为早期胃癌诊断的预警分子。从普通胃炎到胃癌,MG7-Ag参与了胃癌的发展过程,故针对MG7-Ag过表达肿瘤的靶向治疗在临床上成为可能。

2024年10月15日 · MG7-Ag抗原是一种在胃癌细胞膜上表达的糖蛋白，其发现于20世纪80年代。 作为 肿瘤标志物 ，MG7-Ag抗原在胃癌诊断、预后评估及治疗效果检测中发挥着重要作用。

2002年12月12日 · The current study is to investigate the dynamic expression of MG7 antigen in different gastric mucosa, including the normal gastric tissue, H. pylori-associated gastric lesions as well as other precancerous conditions and gastric cancer, also to investigate the influence of H. pylori on MG7 antigen expression.

MG7 is a gastric cancer-specific MAb with high specificity and sensitivity. By using MG7 MAb, we found that MG7Ag was increasingly detected in superficial gastritis, atrophic gastritis, intestinal metaplasia, atypical hyperplasia, and gastric cancer, indicating that …

2015年7月7日 · This study aims to develop a vaccine against gastric cancer by conjugating multi-repeat epitopes of gastric cancer antigen MG7-Ag and TLR7 agonist. The authors demonstrate that this conjugate elicits specific humoral, natural killer, and cytotoxic T lymphocyte responses in mice and can reduce the tumor burden.

mg7抗体是用胃癌细胞株mkn-46-9作为免疫原免疫小鼠制备的胃癌单克隆抗体，其所识别的mg7-ag是新发现的一种胃癌相关抗原[2]。 MG7-Ag为中性糖脂，抗原决定簇位于糖链上，属糖蛋白抗原，具有分泌性抗原的特点，即在细胞内合成，进而分泌到细胞外[3]。