2024年12月25日 · MGAT5 (Alpha-1,6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Diseases associated with MGAT5 include Cataract 13 With Adult I Phenotype and Congenital Disorder Of Glycosylation, Type Iia. Among its related pathways are Translation of Structural Proteins and Infectious disease.

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A is an enzyme that in humans is encoded by the MGAT5 gene. [5][6] This gene encodes mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N- acetyl -glucosaminyltransferase, a glycosyltransferase involved in the synthesis of protein-bound and lipid -bound oligosaccharides.

2001年2月8日 · Here we demonstrate that a deficiency in β1,6 N-acetylglucosaminyltransferase V (Mgat5), an enzyme in the N-glycosylation pathway, lowers T-cell activation thresholds by directly enhancing TCR ...

该基因编码的蛋白质属于糖基转移酶家族。 它催化将 β-1,6-N-乙酰葡糖胺添加到新合成糖蛋白上存在的双触角 N-连接寡糖的 α-连接甘露糖。 它是参与调节糖蛋白寡糖生物合成的最重要的酶之一。 细胞表面糖蛋白上寡糖的改变会导致细胞粘附或迁移行为发生显着变化。 这种酶活性的增加与侵袭性恶性肿瘤的进展有关。 [RefSeq 提供，2011 年 10 月] The protein encoded by this gene belongs to the Glycosyltransferase family.

The results identified Mgat5-mediated beta-1-6-GlcNAc branched N-glycosylation and following activation of EGFR as a potential novel upstream molecular event for PAK1-induced anoikis resistance in hepatoma cells.

Golgi β1,6N-acetylglucosaminyltransferase V (MGAT5) is required in the biosynthesis of β1,6GlcNAc-branched N-linked glycans attached to cell surface...

N-acetylglucosaminyltransferase-V (GnT-V or MGAT5) is a glycosyltransferase involved in cancer metastasis that creates the β1,6-branch on N-glycans of target proteins such as cell adhesion molecules and cell surface receptors. The 3D structure of GnT …

N-乙酰氨基葡萄糖转移酶-V（GnT-V 或 MGAT5）是一种参与癌症转移的糖基转移酶，可在细胞粘附分子和细胞表面受体等靶蛋白的 N-聚糖上产生 β1,6-分支。 GnT-V 的 3D 结构及其催化位点对于与 N-聚糖末端的相互作用至关重要，现已被揭示。 然而，GnT-V如何识别N-聚糖的核心部分或受体的多肽部分仍不清楚。 通过分子动力学模拟和生化实验，我们发现催化袋外的几个残基可能参与了N-聚糖核心部分的识别。 此外，我们的模拟表明，由于 Manα1,6-Man 连接处的构象变 …

2024年3月5日 · Clinical resource with information about MGAT5, Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women., MGAT5 alters the severity of multiple sclerosis., and available tests.

mgat5的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为由该基因编码的蛋白质属于糖基转移酶家族。 它催化加成的β-1,6- N-乙酰氨基葡糖到存在于新合成的糖蛋白双触角N-连接寡糖的α连接的甘露糖。