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Thrombopoietin - Wikipedia
Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene. Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets. It stimulates the production and … 展开
The thrombopoietin gene is located on the long arm of chromosome 3 (q26.3-27). Abnormalities in this gene occur in some hereditary forms of thrombocytosis (high platelet count) and in some cases of leukemia. … 展开
Despite numerous trials, thrombopoietin has not been found to be useful therapeutically. Theoretical uses include the procurement of … 展开
• Hitchcock IS, Kaushansky K (April 2014). "Thrombopoietin from beginning to end". British Journal of Haematology. 165 (2): 259–68. doi 展开
Thrombopoietin is produced in the liver by both parenchymal cells and sinusoidal endothelial cells, as well as in the kidney by proximal convoluted tubule cells. Small amounts are also made by striated muscle and bone marrow stromal cells. In the liver, its production is … 展开
Thrombopoietin was cloned by five independent teams in 1994. Before its identification, its function has been hypothesized for as much … 展开
CC-BY-SA 许可证中的维基百科文本 Megakaryocyte growth and development factor (MGDF): an Mpl
Megakaryocyte growth and development factor (MGDF) is a ligand for the Mpl receptor related to thrombopoietin (TPO). MGDF stimulates megakaryocytopoiesis and thrombopoiesis, and is …
- 作者: Theresa A Kirley Neumann, Maryann Foote
- Publish Year: 2000
化疗诱导的血小板减少症，这 9 个治疗策略你不可不知 - 丁香园
2018年3月28日 · 另一个促血小板生长因子是截取 tpo 的功能片段得到的巨核细胞衍生生长因子（mgdf），将其进一步修饰得到了聚乙二醇化重组人巨核细胞衍生生长因子 (peg-rhumgdf)。
Megakaryocyte growth and development factor (MGDF) …
1995年10月1日 · MGDF is a cytokine that promotes platelet production and function. This study shows that MGDF increases the sensitivity of platelets to aggregating agents and induces …
- 作者: Christopher F. Toombs, Christopher F. Toombs, Cindy H. Young, Cindy H. Young, John A. Glaspy, John A...
- Publish Year: 1995
什么是促血小板生成素(TPO)？ - 知乎
促血小板生成素(tpo)也称为巨核细胞生长发育因子(mgdf)，是由肝脏实质细胞、肝窦内皮细胞和肾小管细胞产生的糖蛋白激素。 横纹肌和骨髓基质细胞也有少量表达。
MGDF stimulates megakaryocytopoiesis in patients with AML in first remission, restoring the Meg-CFC compartment to normal values, a result with potential clinical implications for
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Megakaryocyte Growth and Development Factor: A Review of …
1997年10月1日 · MGDF is a truncated form of thrombopoietin, a cytokine that regulates platelet production. This article summarizes the preclinical and clinical studies of MGDF, a potential …
Megakaryocyte growth and development factor is a potent …
Megakaryocyte growth and development factor (MGDF), or thrombopoietin, has received considerable attention as a therapeutic agent for treating thrombocytopenia or for its use in the …
Megakaryocyte Growth and Development Factor: A Review of …
Megakaryocyte growth and development factor (MGDF), an Mpl ligand, recently entered clinical trials worldwide and has been demonstrated to have potent biological activity. MGDF …
Megakaryocyte growth and development factor (MGDF), or thrombopoietin, has received considerable attention as a thera-peutic agent for treating thrombocytopenia or for its...
