MHC Class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on professional antigen-presenting cells such as dendritic cells, macrophages, some endothelial cells, thymic epithelial cells, and B cells. These cells are important in initiating immune responses.

主要组织相容性复合体（major histocompatibility complex，MHC） 是一组编码动物主要组织相容性抗原的基因群的统称。 人类的MHC被称为 HLA （human leukocyte antigen，HLA）， 即 人白细胞抗原 ;小鼠MHC则被称为H-2。

2024年12月13日 · Major histocompatibility complex class II (MHCII) bound to a peptide antigen mediates interactions between CD4 + T cells and antigen-presenting cells. Targeting peptide–MHCII...

主要组织相容性复合体 （major histocompatibility complex， MHC），又称 主要组织相容性複合基因，是存在于大部分 脊椎动物 基因组 中的一个 基因家族，由一群紧密连锁的基因群组成，呈高度多态性，其编码产物（主要组织相容性抗原）是 抗原提呈 和 T细胞活化 分子，与 免疫应答 及 免疫调节 密切相关，也是引起快而强的排斥反应的抗原；其中人類的MHC醣蛋白，又稱為 人類白血球抗原 （英語：human leukocyte antigen，簡稱HLA）。 MHC基因家族分为三个亚群，分 …

主要组织相容性复合物（Major Histocompatibility Complex，简称MHC）是一组高度变异的基因群，存在于脊椎动物细胞表面。MHC的主要功能是呈递抗原给免疫系统，从而激活T细胞和B细胞的免疫应答。 MHC分为两类：MHC I和MHC II。

Major histocompatibility complex class II proteins fold in the ER in complex with a protein called invariant chain (Ii) and are then transported to late endosomal compartments (also coined MHC class II compartment, MIIC). There, Ii is cleaved by cathepsin proteases and a short fragment remains bound to the peptide-binding groove of MHC class II ...

2013年7月18日 · The Major Histocompatibility complex (MHC) system known as the human leukocyte antigen (HLA) in humans is located on the short arm of chromosome 6 (6p21.3) and contains the most polymorphic gene cluster of the entire human genome.

Presentation of peptide antigens by class II Major Histocompatibility Complex (MHC-II) molecules is critical for maintenance of self-tolerance and for initiation of effective immune responses.

2023年8月31日 · Present MHC-II/peptide complexes to naive T4-lymphocytes or effector T4-lymphocytes that have a complementary shaped T-cell receptor or TCR. Through the process of cross-presentation, some antigen-presenting dendritic cells can cross-present epitopes of endogenous antigens to MHC-II molecules for eventual presentation to naive T4-lymphocytes.

2024年3月11日 · Major histocompatibility complex Class II (MHCII) proteins initiate and regulate immune responses by presentation of antigenic peptides to CD4+ T-cells and self-restriction. The interactions between MHCII and peptides determine the specificity of the immune response and are crucial in immunotherapy and cancer vaccine design.