Compare Fluconazole vs Micafungin head-to-head with other drugs for uses, ratings, cost, side effects and interactions.

2024年8月3日 · Fluconazole shouldn't be used as empiric therapy for invasive Candida infection acquired in the ICU. However, fluconazole may be used as a step-down therapy, following empiric treatment with an echinocandin (if the Candida species is sensitive to fluconazole).

2009年9月1日 · Initial therapy for most nonneutropenic adults with candidemia should be fluconazole (Diflucan) or an echinocandin (e.g., caspofungin [Cancidas], anidulafungin [Eraxis], micafungin [Mycamine]).

Fluconazole, 5FC, and amphotericin B are typically used as primary therapy, although limited experience in patients suggests that voriconazole, posaconazole, caspofungin, and micafungin could also be used for treating fungal peritoneal infection.

2015年12月16日 · Alternatives for fluconazole-refractory disease include an echinocandin (micafungin: 150 mg daily; caspofungin: 70-mg loading dose, then 50 mg daily; or anidulafungin: 200 mg daily) for 14–21 days, OR AmB deoxycholate, 0.3–0.7 mg/kg daily, for 21 days (strong recommendation; high-quality evidence).

2017年7月19日 · Micafungin: In a randomized, double-blind, multicenter, phase III trial, micafungin—an echinocandin—was compared with fluconazole for antifungal prophylaxis in patients who underwent hematopoietic stem-cell transplantation.

2005年4月1日 · Intravenous micafungin (150 mg daily) is well tolerated and as efficacious as intravenous fluconazole (200 mg daily) in the primary treatment of oesophageal candidiasis, achieving high rates of clinical and endoscopic cure.

Invasive candidiasis refers to systemic Candida infection, in the presence or absence of candidemia; examples include osteoarticular infection and hepatosplenic candidiasis. Candidemia is the most common manifestation of invasive candidiasis. The treatment of systemic candidal infection in adults will be reviewed here.

Micafungin was shown to be as effective as both l-amphotericin B and caspofungin in randomized clinical trials [51, 52]. However, the potential risk for developing liver tumors indicates that use should be restricted to when other antifungals are not appropriate.