Mouse models of heart disease have provided valuable insights into mechanisms that occur during cardiac aging and in response to a variety of pathologies. The assessment of cardiovascular physiological responses to injury or insult is an important and necessary component of this research.

2012年8月15日 · Our data offers clear insights into the growth and morphogenesis of the mouse heart and shows that in early development the phases of tube formation and chamber formation overlap. The resulting interactive quantitative 3D atlas of cardiac growth and morphogenesis provides a resource for interpretation of mechanistic studies.

Excess endothelial-to-mesenchymal transition, resulting in increased mesenchymal cells, is the likely cause of morphological heart abnormalities in both humans and mice. In mice, these abnormalities result in progressive and severe diastolic dysfunction, culminating in heart failure."

4 天之前 · Interestingly, mice consuming a high-fat diet for 12 weeks or 24 weeks had reduced Parkin protein levels in the heart compared with mice fed a low-fat diet 166,167, which was associated with ...

2025年3月13日 · The heart is the first organ to become functional during embryonic development in vertebrates. The process begins with the formation of the heart tube, which consists of an inner endothelial lining (endocardium) and a layer of muscle cells (myocardium), separated by a thick extracellular matrix called the cardiac jelly. ... In mice, development ...

2025年3月13日 · The mouse heart is small, with a mass of 150–200 mg, and a setup developed for rat hearts cannot be used without extensive modification. Small cannulas are required to fit into the mouse heart, and these small tubings will lead to significant resistance to flow if they are not kept as short as possible with the largest possible inner diameter

2024年12月31日 · Myocardial infarction (MI) is a life-threatening heart disease characterized by the occlusion in the coronary arteries, leading to a great loss of functional cardiomyocytes.

2024年10月14日 · Postnatal cardiac development requires the orchestrated maturation of diverse cellular components for which unifying control mechanisms are still lacking. Using full-length sequencing, we examined the transcriptomic landscape of the maturating mouse heart (E18.5–P28) at single-cell and transcript isoform resolution.

5 天之前 · Lef treatment attenuated cardiotoxicity in αPD1-treated melanoma mice. αPD1-treated melanoma mice exhibited an impaired cardiac function, as suggested by the decreased ejection fraction (EF) and ...

2025年3月11日 · The mouse heart is a key model in cardiovascular research due to its genetic similarity to the human heart and rapid physiological processes. Examining its structure, conduction system, and microanatomy provides insights into cardiac function, disease mechanisms, and potential treatments.